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Updated: Sep 6, 2025
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Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis
Published on: October 2, 2020
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Cerebral oxygenation changes in response to post-hemodialysis standing
Sojiro Imai1, Susumu Ookawara2, Kiyonori Ito3
1Department of Dialysis, Minami-Uonuma City Hospital, Niigata, Japan.
Summary
Cerebral oxygenation significantly decreases upon standing after hemodialysis (HD). This change is linked to blood pressure and is more pronounced in patients with diabetes mellitus (DM), highlighting a need for attention.
Area of Science:
- Nephrology
- Neurology
- Physiology
Background:
- Cerebral oxygenation changes upon standing after hemodialysis (HD) are not well-documented.
- Blood pressure (BP) regulation is crucial for maintaining adequate cerebral perfusion.
Purpose of the Study:
- To identify factors influencing cerebral regional oxygen saturation (rSO2) changes upon standing post-HD.
- To compare cerebral rSO2 changes between HD patients with and without diabetes mellitus (DM).
Main Methods:
- 43 HD patients were monitored for mean BP and cerebral rSO2 during 120 seconds of standing post-HD.
- An INVOS 5100c oxygen saturation monitor was used.
- Multivariable linear regression analysis was performed.
Main Results:
- Cerebral rSO2 significantly decreased upon standing after HD (-6.8% ± 6.4%).
- This decrease correlated with DM, HD duration, and BP changes.
- Percentage change in cerebral rSO2 was independently associated with percentage change in mean BP post-standing.
Conclusions:
- Cerebral oxygenation significantly deteriorates upon standing after HD.
- Diabetes mellitus exacerbates this post-HD cerebral oxygenation decline.
- Clinical attention is warranted for post-HD cerebral oxygenation, especially in diabetic patients.
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