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Updated: Sep 6, 2025

Proteomics to Identify Proteins Interacting with P2X2 Ligand-Gated Cation Channels
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Proteomics to Identify Proteins Interacting with P2X2 Ligand-Gated Cation Channels

Published on: May 18, 2009

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Using Symmetrical Organic Cation Solutions to Study P2X7 Ion Permeation

Kate Dunning1, Laurie Peverini2, Thomas Grutter3,4,5

  • 1Centre National de la Recherche Scientifique, University of Strasbourg, CAMB UMR 7199, Strasbourg, France.

Methods in Molecular Biology (Clifton, N.J.)
|July 1, 2022
PubMed
Summary

P2X7 receptors form unique macropores permeable to large molecules. Symmetrical organic cation solutions offer a clearer method to study these permeation properties, overcoming artifact-prone techniques.

Keywords:
ATPElectrophysiologyMacroporeNMDGP2X7 ion channelPermeationSpermidine

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