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Malignant hyperthermia during isoflurane anaesthesia. A case report.

G Johannesson, T Veel, J Rogstadius

    Acta Anaesthesiologica Scandinavica
    |April 1, 1987
    PubMed
    Summary

    Malignant hyperthermia can be triggered by isoflurane anesthesia alone, even without muscle relaxants. This case highlights the risk in a healthy child, emphasizing isoflurane

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    <i>FERMI</i>-LAT OBSERVATIONS OF HIGH- AND INTERMEDIATE-VELOCITY CLOUDS: TRACING COSMIC RAYS IN THE HALO OF THE MILKY WAY.

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    Area of Science:

    • Anesthesiology
    • Pharmacology

    Background:

    • Malignant hyperthermia (MH) is a rare, life-threatening pharmacogenetic disorder of skeletal muscle.
    • Volatile anesthetics like isoflurane are known triggers, typically in conjunction with depolarizing muscle relaxants.
    • Understanding MH triggers is crucial for patient safety in surgical settings.

    Observation:

    • A case report details a 7-year-old healthy female experiencing malignant hyperthermia.
    • The patient received isoflurane anesthesia with premedication and nitrous oxide, but no muscle relaxants.
    • This clinical scenario occurred during routine anesthesia administration.

    Findings:

    • Isoflurane, when administered alone without muscle relaxants, can independently trigger malignant hyperthermia.
    • The absence of muscle relaxants in this case challenges the traditional understanding of MH triggering agents.
    • This finding suggests a direct susceptibility to isoflurane in certain individuals.

    Implications:

    • Anesthesiologists should consider isoflurane as a potential MH trigger, even in the absence of muscle relaxants.
    • Further research may be needed to elucidate the specific mechanisms by which isoflurane alone can induce MH.
    • This case underscores the importance of vigilant monitoring for MH symptoms in all patients receiving volatile anesthetics.

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