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Related Concept Videos

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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The basal lamina is a thin extracellular layer that lies underneath the cells and separates them from other tissues. The three layers of the basal lamina are lamina lucida, lamina densa and lamina reticularis. The basal lamina, a mixture of glycoproteins and collagen, provides an attachment site for the epithelium, separating it from underlying connective tissue. The framework of basal lamina has other essential proteins such as laminins mesh, perlecan, entactin, and type IV collagen.
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Updated: Sep 6, 2025

Cell Population Analyses During Skin Carcinogenesis
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Cell Population Analyses During Skin Carcinogenesis

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Basal cell carcinoma.

Richard P Usatine1, Candrice R Heath2

  • 1Family and Community Medicine, Dermatology and Cutaneous Surgery, University of Texas Health, San Antonio.

The Journal of Family Practice
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Summary
This summary is machine-generated.

Nodular basal cell carcinoma (BCC) can present differently across skin tones. Early identification of subtle signs like pearly borders is crucial for diagnosis in diverse populations.

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Area of Science:

  • Dermatology
  • Oncology

Background:

  • Basal cell carcinoma (BCC) is the most common type of skin cancer.
  • Clinical presentation of BCC can vary, particularly in individuals with different skin tones.

Observation:

  • Case 1: An 80-year-old Hispanic woman with light skin tone presented with a nodular BCC on her forehead exhibiting classic features: pearly rolled border, central pigmentation, and telangiectasia.
  • Case 2: A 64-year-old Black man with dark skin tone presented with a nodular BCC on his cheek as a dark, nonhealing ulcer with a subtle, pearly, rolled border and no visible telangiectasia.

Findings:

  • Nodular BCC can manifest with varied clinical signs, including the presence or absence of telangiectasia.
  • Pigmentation and subtle pearly rolled borders are key diagnostic indicators, even in darker skin tones.

Implications:

  • Recognizing the diverse presentations of nodular BCC is essential for accurate and timely diagnosis in all skin types.
  • Dermatologists should consider subtle diagnostic clues in non-healing ulcers, especially in patients with darker skin tones.