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Verteporfin protects against Th17 cell-mediated EAE independently of YAP inhibition
Paulin Brosinsky1, Hanna Leister1, Nan Cheng2
1Institute for Medical Microbiology and Hygiene, Philipps-University Marburg, Marburg, Germany.
Abstract:
The known YAP inhibitor verteporfin is capable of repressing IL-17A production in Th17 cells. However, this effect is mediated independently of YAP and can ameliorate Th17-mediated experimental autoimmune encephalomyelitis (EAE) upon in vivo administration. The data suggest verteprofin's mode of action for the design of novel therapeutic autoimmune disease intervention.
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