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The emerging role of miR-653 in human cancer

Moussa Omorou1, Yiwei Huang1, Ning Liu1

  • 1Department of Biochemistry and Molecular Biology, Jiamusi University School of Basic Medical Sciences, Jiamusi, Heilongjiang 154000, PR China.

Cancer Epidemiology
|July 1, 2022
PubMed

Insights

MicroRNA 653 (miR-653) shows varied roles in human cancers, acting as a tumor suppressor in some and a promoter in others. Targeting miR-653 may offer new diagnostic and therapeutic strategies for cancer.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs involved in gene regulation.
  • Deregulation of miRNA expression is linked to various pathologies, including cancer, hypoxia, and stroke.

Purpose of the Study:

  • To summarize the expression levels and molecular functions of miR-653 in human cancers.
  • To investigate the dual role of miR-653 in cancer progression and prognosis.

Main Methods:

  • Literature review and analysis of existing studies on miR-653 in human cancer.
  • Examination of miR-653 expression patterns and its correlation with tumor aggressiveness and patient outcomes.

Main Results:

  • miR-653 expression variations correlate with tumor aggressiveness and prognosis.
  • miR-653 acts as a tumor suppressor in breast, cervical, liver, renal, and lung cancers.
  • miR-653 acts as an oncogene in bladder and prostate cancers, with a controversial role in gastric cancer.

Conclusions:

  • miR-653 exhibits context-dependent roles in human cancer, acting as either an oncogene or tumor suppressor.
  • Targeting miR-653 presents a potential novel strategy for cancer diagnosis and treatment.
  • Further research is needed to clarify the role of miR-653 in gastric cancer.
Keywords:
ApoptosisCancerMetastasisMiR-653

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