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Related Experiment Video

Updated: Sep 6, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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What SARS-CoV-2 does to our brains.

Tom Aschman1, Ronja Mothes1, Frank L Heppner2

  • 1Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Department of Neuropathology, Charitéplatz 1, 10117 Berlin, Germany.

Immunity
|July 1, 2022
PubMed
Summary

The cause of neurological symptoms in SARS-CoV-2 infection is unclear. This study suggests focusing on the immune system's reaction to the virus, rather than direct viral brain infection, to understand these neurocognitive effects.

Keywords:
NeuroimmunologySARS-CoV-2neurotropismsickness behaviour

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Area of Science:

  • Neuroscience
  • Immunology
  • Infectious Diseases

Background:

  • Neurological symptoms are frequently reported in patients with SARS-CoV-2 infection.
  • The precise mechanisms underlying these neurological manifestations remain largely undetermined.

Purpose of the Study:

  • To explore potential immune-mediated mechanisms responsible for central nervous system (CNS) alterations in SARS-CoV-2 infection.
  • To review existing literature on CNS involvement during COVID-19 and related animal studies.

Main Methods:

  • Literature review of studies on COVID-19 and neurological symptoms.
  • Analysis of potential immune responses and their impact on the CNS.
  • Examination of animal models for insights into sickness behavior pathways.

Main Results:

  • Direct evidence of SARS-CoV-2 in the CNS is currently lacking.
  • Immune system responses are proposed as a key factor in neurocognitive symptoms.
  • Both acute and post-infectious immune-mediated mechanisms are considered.

Conclusions:

  • The host's immune reaction is a critical focus for understanding neurocognitive symptoms post-SARS-CoV-2.
  • Immune-mediated pathways likely contribute to functional and structural CNS changes.
  • Further research into immune mechanisms is warranted for both acute and long-term neurological effects.