Related Experiment Video

Updated: Sep 6, 2025

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
11:32

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter

Published on: March 27, 2020

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YAP and TAZ: Monocorial and bicorial transcriptional co-activators in human cancers

Federica Lo Sardo1, Valeria Canu1, Marcello Maugeri-Saccà2

  • 1Translational Oncology Research Unit, Department of Research, Diagnosis and Innovative Technologies, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

Biochimica Et Biophysica Acta. Reviews on Cancer
|July 1, 2022
PubMed

Insights

The transcriptional regulators YAP and TAZ have distinct roles in health and cancer. Understanding these differences is crucial for developing targeted cancer therapies that selectively inhibit YAP or TAZ.

Area of Science:

  • Molecular Biology
  • Oncology
  • Cell Biology

Background:

  • The transcriptional regulators YAP (Yes-associated protein) and TAZ (Tazo) are key players in cellular processes.
  • Dysregulation of YAP and TAZ is implicated in cancer development.
  • YAP and TAZ are often studied together as YAP/TAZ, but possess unique functions.

Purpose of the Study:

  • To review the distinct roles of YAP and TAZ, with a focus on their involvement in cancer.
  • To highlight the importance of differentiating YAP and TAZ functions for therapeutic strategies.
  • To emphasize the need for careful evaluation of targeted therapies against YAP or TAZ.

Main Methods:

  • Literature review of experimental evidence on YAP and TAZ functions.
  • Analysis of distinct upstream regulatory cues for YAP and TAZ.
  • Examination of the implications of YAP and TAZ dysregulation in tumorigenesis.

Main Results:

  • YAP and TAZ regulate both overlapping and distinct physiological and pathological processes.
  • Distinct upstream signals control YAP and TAZ activity.
  • Targeting YAP or TAZ selectively may impact different pathways, leading to varied clinical outcomes.

Conclusions:

  • YAP and TAZ are not interchangeable and exhibit unique functions.
  • Therapeutic strategies targeting YAP and TAZ require careful consideration of their individual roles.
  • Selective inhibition of YAP or TAZ could offer distinct therapeutic benefits or challenges in cancer treatment.
Keywords:
Breast cancerCRCLung cancerTAZTherapyYAP

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