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Reduced-gravity Environment Hardware Demonstrations of a Prototype Miniaturized Flow Cytometer and Companion Microfluidic Mixing Technology

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Microcompartment assembly around multicomponent fluid cargoes.

Lev Tsidilkovski¹, Farzaneh Mohajerani¹, Michael F Hagan¹

¹Martin A. Fisher School of Physics, Brandeis University, Waltham, Massachusetts 02453, USA.

The Journal of Chemical Physics

|July 1, 2022

Summary

This summary is machine-generated.

Protein shell assembly around fluid cargo is influenced by component interactions. These findings inform synthetic biology and suggest roles in cellular organization.

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Area of Science:

Biophysics
Systems Biology
Synthetic Biology

Background:

Bacterial microcompartments are protein shells encapsulating metabolic enzymes.
Understanding their assembly is key for biological function and synthetic applications.

Purpose of the Study:

To simulate the assembly of icosahedral protein shells around bicomponent fluid cargo.
To investigate the influence of component interactions on encapsulation and organization.

Main Methods:

Dynamical simulations of protein shell assembly.
Modeling of bicomponent fluid cargo and shell protein interactions.

Main Results:

Relative interaction strengths dictate cargo encapsulation amounts and spatial organization.
Shell protein interactions influence cargo composition via thermodynamic and kinetic effects.
Coupling between self-assembly and liquid-liquid phase separation is suggested.

Conclusions:

Protein-protein and protein-cargo interactions are critical for microcompartment assembly and function.
Results guide synthetic biology efforts to engineer novel microcompartments.
Findings suggest a broader role for self-assembly and phase separation in cellular organization.