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Updated: Jun 7, 2026
Human Placental and Decidual Organ Cultures to Study Infections at the Maternal-fetal Interface
Published on: July 21, 2016
Perinatal COVID-19 maternal and neonatal outcomes at two academic birth hospitals
Dustin D Flannery1,2,3, Alvaro Zevallos Barboza4, Madeline R Pfeifer4
1Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA. flanneryd@chop.edu.
Objective:
Describe 1-month outcomes among newborns of persons with perinatal COVID-19.
Study Design:
Prospective observational study of pregnant persons who tested positive for SARS-CoV-2 between 14 days before and 3 days after delivery and their newborns, from 3/2020 to 3/2021 at two urban high-risk academic hospitals. Phone interviews were conducted to determine 1-month newborn outcomes.
Results:
Among 9748 pregnant persons, 209 (2.1%) tested positive for perinatal SARS-CoV-2. Symptomatically infected persons were more likely to have a preterm delivery due to worsening maternal condition and their newborns were more likely to test positive for SARS-CoV-2 compared with asymptomatic persons. Six of 191 (3.1%) infants tested were positive for SARS-CoV-2; none had attributable illness before discharge. Of 169 eligible families, 132 (78.1%) participated in post-discharge interviews; none reported their newborn tested positive for SARS-CoV-2 by 1 month of age.
Conclusion:
Symptomatic perinatal COVID-19 had a substantial effect on maternal health but no apparent short-term effect on newborns.
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