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Updated: Sep 6, 2025

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
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Hypertrophic Cardiomyopathy in the Elderly: A Case Identified With Genetic Screening

Gaspar Del Rio-Pertuz1, Pooja Sethi2, Deephak Swaminath2

  • 1Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.

Journal of Investigative Medicine High Impact Case Reports
|July 2, 2022
PubMed

Insights

Hypertrophic cardiomyopathy (HCM) is a genetic heart condition. This case highlights that HCM can also affect the elderly, presenting later in life.

Area of Science:

  • Cardiology
  • Genetics
  • Geriatrics

Background:

  • Hypertrophic cardiomyopathy (HCM) is an inherited cardiac disease.
  • It is caused by mutations in sarcomere genes, affecting heart contractility.
  • Typically diagnosed in younger individuals, presenting with syncope or sudden cardiac death.

Observation:

  • A case of late-onset HCM in a 73-year-old woman is presented.
  • The patient experienced various clinical events leading to diagnosis.
  • This highlights the potential for HCM in the elderly population.

Findings:

  • HCM can manifest in older adults, challenging typical diagnostic timelines.
  • Improved genetic understanding and imaging aid in recognizing late-onset forms.
  • Genetic factors and cardiac function in elderly HCM patients warrant further study.

Implications:

  • Recognizing late-onset HCM is crucial for accurate diagnosis and management in elderly patients.
  • This expands the known clinical spectrum of hypertrophic cardiomyopathy.
  • Further research into the genetic and clinical characteristics of elderly HCM is needed.

Keywords:
elderlygenetic screeninghypertrophic cardiomyopathyrecognition

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