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Related Experiment Video

Updated: Sep 6, 2025

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
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Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

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Hypophysitis.

Diane Donegan1, Jürgen Honegger2

  • 1Division of Endocrinology, Indiana University, Indianapolis, Indiana.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
|July 2, 2022
PubMed
Summary
This summary is machine-generated.

Hypophysitis, an inflammatory pituitary gland disease, is increasingly recognized, especially as an immune-related adverse event from cancer immunotherapy. Early diagnosis and management, focusing on symptom relief and hormone replacement, are crucial.

Keywords:
adenohypophysitisautoimmune hypophysitisinfundibuloneurohypophysitispanhypophysitis

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Area of Science:

  • Endocrinology
  • Immunology
  • Oncology

Background:

  • Hypophysitis is a rare inflammatory pituitary gland disease.
  • Primary autoimmune hypophysitis was historically the most recognized form.
  • Increased recognition due to immunotherapy-induced immune-related adverse events.

Purpose of the Study:

  • To review epidemiology, diagnosis, and treatment of hypophysitis.
  • To highlight recent data and specific subtypes.
  • To identify knowledge gaps in hypophysitis management.

Main Methods:

  • Literature review focusing on recent data.
  • Discussion of diagnostic criteria and therapeutic approaches.
  • Analysis of hypophysitis subtypes.

Main Results:

  • Symptoms include mass effect (headache, visual disturbance) and hormonal disruption.
  • Diagnosis is often presumptive, based on clinical context and imaging, after excluding other causes.
  • Radiologic findings are key for presumptive diagnosis.

Conclusions:

  • Management focuses on symptom control and hormone replacement therapy.
  • Subtle differences exist in managing primary vs. secondary hypophysitis.
  • Prompt evaluation for symptoms is warranted.