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Antinociceptive and Analgesic Effects of (2R,6R)-Hydroxynorketamine

Jonathan G Yost1, Hildegard A Wulf1, Caroline A Browne1

  • 1Neuroscience Graduate Program (J.G.Y., C.A.B., I.L.), Department of Pharmacology and Molecular Therapeutics (H.A.W., C.A.B., I.L.), and Department of Psychiatry (I.L.), Uniformed Services University, Bethesda, Maryland.

The Journal of Pharmacology and Experimental Therapeutics
|July 2, 2022
PubMed
Summary

(2R,6R)-hydroxynorketamine (HNK), a ketamine metabolite, offers pain relief via AMPA receptors with a better safety profile than ketamine. HNK also effectively treats neuropathic pain, outperforming gabapentin over time.

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