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Sequence of flexion contracture development in the lower limb: a longitudinal analysis of 1,071 children with
Erika Cloodt1,2, Anna Lindgren3, Henrik Lauge-Pedersen4
1Department of Clinical Sciences Lund, Orthopaedics, Lund University, Lund, Sweden. erika.cloodt@med.lu.se.
Insights
Contractures in children with cerebral palsy (CP) often appear in predictable patterns. Understanding these sequences, especially related to hip, knee, and ankle contractures, can guide early intervention for improved mobility.
Area of Science:
- Orthopedics
- Pediatric Rehabilitation
- Movement Science
Background:
- Cerebral palsy (CP) frequently leads to contractures, impacting joint range of motion and function.
- Early identification and management of contractures are essential to prevent secondary complications and preserve joint function in children with CP.
Purpose of the Study:
- To investigate the sequential development of hip, knee, and ankle contractures in children with CP.
- To determine the association between primary contracture location and the subsequent development of contractures in adjacent joints.
Main Methods:
- Longitudinal cohort study of 1,071 children with CP, followed for an average of 4.6 years.
- Analysis included 1,636 legs with initial hip, knee, or ankle flexion contracture (≥10°).
- Cox proportional-hazards models adjusted for Gross Motor Function Classification System (GMFCS) levels were used.
Main Results:
- A second contracture developed in 44% of legs, increasing with higher GMFCS levels.
- Primary hip or foot contractures were associated with a higher likelihood of developing a secondary knee contracture.
- Primary knee contractures often preceded the development of hip or ankle contractures.
Conclusions:
- Lower limb contractures in CP exhibit specific sequential patterns.
- The GMFCS level and the location of the initial contracture significantly influence the development of subsequent contractures in adjacent joints.
Background:
To prevent severe contractures and their impact on adjacent joints in children with cerebral palsy (CP), it is crucial to treat the reduced range of motion early and to understand the order by which contractures appear. The aim of this study was to determine how a hip-knee or ankle contracture are associated with the time to and sequence of contracture development in adjacent joints.
Methods:
This was a longitudinal cohort study of 1,071 children (636 boys, 435 girls) with CP born 1990 to 2018 who were registered before 5 years of age in the Swedish surveillance program for CP and had a hip, knee or ankle flexion contracture of ≥ 10°. The results were based on 1,636 legs followed for an average of 4.6 years (range 0-17 years). The Cox proportional-hazards model adjusted for Gross Motor Function Classification System (GMFCS) levels I-V was used to compare the percentage of legs with and without more than one contracture.
Results:
A second contracture developed in 44% of the legs. The frequency of multiple contractures increased with higher GMFCS level. Children with a primary hip or foot contracture were more likely to develop a second knee contracture. Children with a primary knee contracture developed either a hip or ankle contracture as a second contracture.
Conclusions:
Multiple contractures were associated with higher GMFCS level. Lower limb contractures appeared in specific patterns where the location of the primary contracture and GMFCS level were associated with contracture development in adjacent joints.
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