Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Exercise thallium testing in ventricular preexcitation.

S Archer, C Gornick, F Grund

    The American Journal of Cardiology
    |May 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Gut Microbiome and Pulmonary Arterial Hypertension - A Novel and Evolving Paradigm.

    Physiological research·2024
    Same author

    Hypoxic Pulmonary Vasoconstriction: An Important Component of the Homeostatic Oxygen Sensing System.

    Physiological research·2024
    Same author

    The Benefits of a Rapid Access Pathway for Patients Requiring Single Fraction Radiotherapy Treatment: The Cambridge Experience.

    Clinical oncology (Royal College of Radiologists (Great Britain))·2024
    Same author

    Qualitative analysis of mental health conversational agents messages about autism spectrum disorder: a call for action.

    Frontiers in digital health·2023
    Same author

    Readmissions to hospital following a decision to eat and drink with acknowledged risk.

    Geriatric nursing (New York, N.Y.)·2023
    Same author

    Genetic investigation of equine recurrent uveitis in Appaloosa horses.

    Animal genetics·2019
    Same journal

    Real-World Effectiveness and Tolerability of Sacubitril/Valsartan in Octogenarian Patients With Heart Failure: Results From the PARACHUTER Study.

    The American journal of cardiology·2026
    Same journal

    ECG-Guided Conduction Pathways as a Lever to Shorten Post-TAVI Hospitalization.

    The American journal of cardiology·2026
    Same journal

    Cystatin-C versus creatinine and kidney function in heart failure with preserved ejection fraction: a SOGALDI-PEF analysis.

    The American journal of cardiology·2026
    Same journal

    Balloon-expandable versus Self-expanding Valves in Patients with Small Aortic Annuli Undergoing Transcatheter Aortic Valve Replacement.

    The American journal of cardiology·2026
    Same journal

    Drug-Coated Balloons versus Drug-Eluting Stents following Coronary Atherectomy in Severely Calcified Lesions: A Systematic Review and Meta-Analysis.

    The American journal of cardiology·2026
    Same journal

    Prehospital Statin Therapy and Outcomes in ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.

    The American journal of cardiology·2026
    See all related articles

    Ventricular preexcitation, common in Wolff-Parkinson-White syndrome, often causes abnormal exercise thallium test results. This suggests exercise radionuclide ventriculography may be a better tool for assessing coronary artery disease in these patients.

    Area of Science:

    • Cardiology
    • Nuclear Cardiology
    • Electrophysiology

    Background:

    • Ventricular preexcitation, seen in Wolff-Parkinson-White syndrome, frequently leads to positive exercise electrocardiographic responses.
    • The underlying mechanism for these false-positive results is not fully understood and is not attributed to myocardial ischemia.
    • Exercise thallium testing is a standard noninvasive method for evaluating coronary artery disease, particularly in patients with conditions causing false-positive ECGs.

    Purpose of the Study:

    • To investigate the impact of ventricular preexcitation on the accuracy of exercise thallium testing.
    • To determine if ventricular preexcitation itself can lead to abnormal thallium test findings.
    • To explore alternative noninvasive methods for assessing coronary artery disease in patients with ventricular preexcitation.

    Related Experiment Videos

    Main Methods:

    • Studied 8 male patients with ventricular preexcitation (mean age 42 years) and no coronary artery disease symptoms.
    • Subjects underwent bicycle ergometer exercise testing to a target double product.
    • Exercise thallium testing was performed, with subsequent analysis of perfusion defects and thallium washout.
    • Coronary angiography and exercise radionuclide ventriculography were used in select cases for further assessment.

    Main Results:

    • Exercise thallium tests were abnormal in 5 out of 8 subjects (62.5%).
    • Two patients showed stress defects and delayed thallium washout; one had normal coronary angiography and ergonovine testing.
    • Three subjects exhibited delayed thallium washout despite normal stress imaging.
    • No patient experienced chest pain during testing, with exercise limited by fatigue or dyspnea.

    Conclusions:

    • Exercise thallium testing frequently yields abnormal results in individuals with ventricular preexcitation.
    • Ventricular preexcitation may induce myocardial thallium handling abnormalities due to dyssynergic ventricular activation.
    • Exercise radionuclide ventriculography may offer a more reliable noninvasive assessment of coronary artery disease in patients with ventricular preexcitation.