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Updated: Sep 6, 2025
In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
Published on: October 21, 2022
CircRNAs in lung cancer- role and clinical application
Jingwei Li1, Qiran Zhang1, Decheng Jiang2
1Department of Respiratory and Critical Care Medicine, Med-X Center for Manufacturing, Frontiers Science Center for Disease-related Molecular Network, West China Medical School/West China Hospital, Sichuan University, Chengdu, China.
Abstract:
Lung cancer holds the highest mortality rate among malignancies worldwide. Nevertheless, the potential molecular mechanisms of its tumorigenesis and evolution remain obscure. Circular RNAs (circRNAs), a broad category of covalently closed molecules, follow a malignancy-restricted expression pattern. Leading-edge studies have demonstrated the clinical application prospects of circRNAs in lung cancer. Herein, this review elucidates the biogenesis, biological functions, and pathophysiology of circRNAs. Furthermore, we underscore the forefront of the diagnostic, prognostic, and therapeutic potential of circRNAs in lung cancer as well as discuss the bottleneck that needs to be overcome to translate the basic advances of circRNAs into clinical practice.
Insights
Circular RNAs (circRNAs) show promise for lung cancer diagnosis and treatment. This review explores their role in lung cancer, from biogenesis to clinical applications.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Lung cancer is a leading cause of cancer mortality globally.
- The molecular mechanisms underlying lung cancer development are not fully understood.
- Circular RNAs (circRNAs) are increasingly recognized for their roles in various cancers.
Purpose of the Study:
- To review the biogenesis, functions, and pathophysiology of circRNAs in lung cancer.
- To highlight the diagnostic, prognostic, and therapeutic potential of circRNAs in lung cancer.
- To discuss challenges in translating circRNA research into clinical practice.
Main Methods:
- Literature review of studies on circRNAs and lung cancer.
- Synthesis of current knowledge on circRNA biogenesis and function.
- Analysis of the clinical relevance of circRNAs in lung cancer.
Main Results:
- CircRNAs exhibit malignancy-restricted expression patterns.
- CircRNAs play significant roles in lung cancer progression.
- Emerging evidence supports circRNAs as biomarkers and therapeutic targets.
Conclusions:
- CircRNAs represent a promising area for lung cancer research.
- Further investigation is needed to overcome obstacles for clinical translation.
- CircRNAs hold potential for improving lung cancer diagnostics and therapeutics.
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