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Experimental Model of Ligature-Induced Peri-Implantitis in Mice
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Peri-implant crevicular fluid SIRT1 levels decrease in patients with peri-implant inflammatory: A prospective

Zhuo Wang1

  • 1Department of Stomatology, Shanghai Oriental Hospital, Shanghai 200120, China.

Transplant Immunology
|July 5, 2022
PubMed
Summary
This summary is machine-generated.

Sirtuin1 (SIRT1) levels in peri-implant crevicular fluid are lower in patients with peri-implant mucositis (PIM) and peri-implantitis (PI). Low SIRT1 correlates with inflammation, suggesting its potential as a diagnostic biomarker for implant complications.

Keywords:
Dental implantsDentition defectPIPIMSIRT1

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Area of Science:

  • Biomaterials Science
  • Molecular Biology
  • Periodontology

Background:

  • Dental implants are prosthetic devices supporting dental prostheses.
  • Sirtuin1 (SIRT1) is a key regulator of cellular processes, including inflammation and apoptosis.
  • Peri-implant mucositis (PIM) and peri-implantitis (PI) are inflammatory conditions affecting dental implants.

Purpose of the Study:

  • To investigate the correlation between Sirtuin1 (SIRT1) expression and inflammatory conditions around dental implants.
  • To assess SIRT1 as a potential diagnostic biomarker for peri-implant mucositis (PIM) and peri-implantitis (PI).

Main Methods:

  • 198 patients were categorized into healthy peri-implant (PIH), PIM, and PI groups.
  • Peri-implant crevicular fluid (PICF) was collected and analyzed for SIRT1 and cytokine levels using ELISA.
  • Clinical data including probing depth, plaque index, and patient-reported outcomes were recorded.

Main Results:

  • Patients with PIM and PI exhibited significantly higher clinical scores (PD, PLI, OHIP-14) than the PIH group.
  • SIRT1 levels in PICF were significantly lower in patients with PIM and PI compared to PIH.
  • SIRT1 levels negatively correlated with pro-inflammatory cytokines (IL-6, CRP, IL-1β) in PIM and PI patients.

Conclusions:

  • Reduced SIRT1 levels in PICF are associated with peri-implant inflammation (PIM and PI).
  • SIRT1 may serve as a valuable diagnostic biomarker for detecting inflammatory processes around dental implants.
  • SIRT1, inflammatory cytokines, and a history of periodontitis are identified as risk factors for peri-implant inflammatory conditions.