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Cancer-associated transcription factors in DNA damage response

Mateusz Kciuk1, Adrianna Gielecińska2, Damian Kołat3

  • 1Department of Molecular Biotechnology and Genetics, University of Lodz, Banacha 12/16, 90-237 Lodz, Poland; University of Lodz, Doctoral School of Exact and Natural Sciences, Banacha Street 12/16, 90-237 Lodz, Poland.

Biochimica Et Biophysica Acta. Reviews on Cancer
|July 5, 2022
PubMed

Insights

This review explores how transcription factors (TFs) like HIF1α, MYC, TWIST, ZEB1, and ZNF281 influence DNA damage response (DDR) pathways. Understanding these TF roles is crucial for cancer research and developing targeted therapies.

Area of Science:

  • Molecular Biology
  • Cancer Biology
  • Genetics

Background:

  • Transcription factors (TFs) regulate gene expression and are implicated in cancer.
  • Emerging evidence highlights TF involvement in the DNA damage response (DDR) pathway.
  • TFs can modulate DDR pathways, impacting DNA repair efficacy and cancer progression.

Purpose of the Study:

  • To review recent findings on the roles of specific TFs in the DDR.
  • To examine TFs with known roles in oncogenesis and metastasis, and their DDR functions.
  • To investigate the association between epithelial-mesenchymal transition (EMT) TFs and canonical DDR pathways.

Main Methods:

  • Literature review of recent scientific reports.
  • Focus on established TFs with dual roles in cancer and DDR.
  • Analysis of TFs including hypoxia-inducible factor-1 α (HIF1α), MYC, TWIST, ZEB1, and ZNF281.

Main Results:

  • HIF1α and MYC, known oncogenic TFs, impact DDR pathways.
  • EMT-associated TFs (TWIST, ZEB1, ZNF281) also play roles in regulating DDR.
  • These TFs influence the effectiveness of DNA repair mechanisms.

Conclusions:

  • Specific TFs critically influence the DNA damage response.
  • Understanding TF-DDR interactions provides insights into cancer development and metastasis.
  • Targeting these TFs may offer novel therapeutic strategies for cancer treatment.
Keywords:
DNA damage response (DDR)DNA repairEpithelial-mesenchymal transition (EMT)MetastasisTranscription factors (TFs)

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