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Updated: Sep 6, 2025

Terminal H-reflex Measurements in Mice
05:38

Terminal H-reflex Measurements in Mice

Published on: June 16, 2022

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Terminal H-reflex Measurements in Mice.

Frederique Wieters1, Matthias Gruhn2, Ansgar Büschges2

  • 1Faculty of Medicine and University Hospital Cologne, Department of Neurology, University of Cologne.

Journal of Visualized Experiments : Jove
|July 5, 2022
PubMed
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This study introduces a precise method to measure the Hoffmann reflex (H-reflex) directly on nerves, aiding in the diagnosis of post-stroke spasticity. This technique offers a reliable tool for evaluating neural circuit integrity in disease models.

Area of Science:

  • Neuroscience
  • Electrophysiology
  • Neurology

Background:

  • The Hoffmann reflex (H-reflex) serves as an electrophysiological measure for assessing neural circuit integrity after injuries like stroke.
  • Increased H-reflex response, alongside symptoms such as hypertonia and involuntary muscle contractions, indicates post-stroke spasticity (PSS).
  • Current transcutaneous measurements lack nerve specificity, limiting precise diagnostic capabilities.

Purpose of the Study:

  • To develop and present a protocol for directly quantifying the H-reflex at specific nerves (ulnar, median, tibial, sciatic).
  • To establish a reliable and versatile electrophysiological tool for validating changes in spasticity-related disease models.

Main Methods:

  • Direct stimulation and quantification of the H-reflex at the ulnar and median nerves of the forepaw.

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Last Updated: Sep 6, 2025

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  • Adaptation of the protocol for application to the tibial and sciatic nerves of the hindpaw.

    • Main Results:

    • The presented protocol allows for direct, nerve-specific measurement of the H-reflex.
    • The method is adaptable to different nerves, demonstrating versatility.

    Conclusions:

    • This direct H-reflex quantification method provides a reliable tool for electrophysiological validation of spasticity in disease models.
    • The protocol enhances the specificity of H-reflex measurements compared to transcutaneous approaches, improving diagnostic accuracy for conditions like PSS.