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Updated: Sep 6, 2025

In Situ Monitoring of Diffusion of Guest Molecules in Porous Media Using Electron Paramagnetic Resonance Imaging
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Fast and accurate diffusion NMR acquisition in continuous flow.

Isabel A Thomlinson1,2,3, Matthew G Davidson1,3, Catherine L Lyall2,3

  • 1Centre for Sustainable and Circular Technologies, University of Bath, Claverton Down, Bath BA2 7AY, UK. u.hintermair@bath.ac.uk.

Chemical Communications (Cambridge, England)
|July 5, 2022
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Summary
This summary is machine-generated.

FlowNMR spectroscopy enables online reaction monitoring. This study introduces FlowDOSY NMR, allowing accurate diffusion measurements in under five minutes at high flow rates.

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Area of Science:

  • Analytical Chemistry
  • Spectroscopy
  • Physical Chemistry

Background:

  • FlowNMR spectroscopy is a key technique for real-time reaction monitoring.
  • Diffusion Ordered SpectroscopY (DOSY) NMR provides insights into molecular size and diffusion in static samples.
  • Integrating these techniques presents a challenge due to flow dynamics.

Purpose of the Study:

  • To extend the FlowNMR technique to include DOSY measurements.
  • To develop a robust FlowDOSY method capable of accurate diffusion coefficient determination.
  • To enable rapid, online analysis of molecular diffusion during reactions.

Main Methods:

  • Development of a FlowDOSY method incorporating convection compensation.
  • Utilized a low-pulsation pump and flow effect correction for enhanced precision.
  • Optimized experimental parameters for high-throughput analysis.

Main Results:

  • Achieved accurate and precise diffusion coefficients using FlowDOSY.
  • Demonstrated the method's efficacy at flow rates up to 4.0 mL min⁻¹.
  • Acquired diffusion data in under 5 minutes, showcasing rapid analysis.

Conclusions:

  • FlowDOSY is a powerful extension of the FlowNMR toolbox.
  • This method facilitates efficient online reaction monitoring with diffusion analysis.
  • Enables faster and more precise characterization of molecular diffusion in flowing systems.