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[Current status of persistent chronic hyperkalaemia in France: An expert consensus based on a Delphi approach]

Patrick Rossignol1, Bruno Moulin2, Jean-Michel Halimi3

  • 1Université de Lorraine, Inserm, Centre d'Investigations Cliniques - Plurithématique 14-33, and Inserm U1116, CHRU Nancy, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), 4 rue du Morvan, 54500 Vandœuvre-lès-Nancy, France.

Nephrologie & Therapeutique
|July 5, 2022
PubMed

Insights

Persistent hyperkalaemia management lacks consensus in France. New strategies are needed for patients with risk factors like chronic kidney disease, especially those on renin-angiotensin-aldosterone system inhibitors, as current treatments are insufficient.

Area of Science:

  • Nephrology
  • Internal Medicine
  • Clinical Practice Guidelines

Background:

  • No current consensus document exists in France for managing persistent hyperkalaemia.
  • Observed variability in clinical practices regarding hyperkalaemia management.

Purpose of the Study:

  • To develop a consensus statement on the definition and management of persistent hyperkalaemia.
  • To address the unmet medical need in persistent hyperkalaemia management.

Main Methods:

  • A Delphi panel of French nephrologists convened between December 2019 and June 2020.
  • Two rounds of voting were conducted with 26 and 20 participants, respectively.

Main Results:

  • Persistent hyperkalaemia is defined as two or more episodes yearly despite cation-exchange resins or loop diuretics.
  • Diabetes, advanced chronic kidney disease (stage 3B-5), and heart failure increase persistent hyperkalaemia risk.
  • Current treatments, including cation-exchange resins, are insufficient for patients on renin-angiotensin-aldosterone system inhibitors.

Conclusions:

  • The consensus panel identified a need for novel treatment strategies.
  • Clinical trials are required to validate new approaches for persistent hyperkalaemia.
Abstract

Keywords:
Chélateurs du potassiumConsensus DelphiDelphi consensusHyperkalaemiaHyperkaliémieInhibiteurs du système rénine-angiotensine-aldostéroneInsuffisance rénaleKidney diseasePotassium bindersRenin-angiotensin-aldosterone system inhibitors

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