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[Challenges in kidney disease: therapeutic potential of bardoxolone methyl]

Kengo Yamawaki1

  • 1R&D division, Development Management Office, Kyowa Kirin Co., Ltd.

Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
|July 5, 2022
PubMed

Insights

Bardoxolone methyl activates the Keap1-Nrf2 pathway, offering therapeutic potential for kidney diseases. Clinical studies show it increases glomerular filtration rate (GFR), addressing a critical need for effective treatments.

Area of Science:

  • Nephrology
  • Pharmacology
  • Oxidative Stress Research

Background:

  • Kidney diseases affect many globally, diminishing patient quality of life.
  • Oxidative stress and inflammation are implicated in kidney disease progression.
  • The Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) pathway is crucial for antioxidant and anti-inflammatory responses.

Purpose of the Study:

  • To review the therapeutic potential of bardoxolone methyl for kidney diseases.
  • To summarize the developmental history and current status of bardoxolone methyl.

Main Methods:

  • Review of existing clinical studies and developmental data.
  • Analysis of bardoxolone methyl's mechanism of action via the Keap1-Nrf2 pathway.

Main Results:

  • Bardoxolone methyl is a potent activator of the Keap1-Nrf2 pathway.
  • Clinical studies indicate bardoxolone methyl increases glomerular filtration rate (GFR).

Conclusions:

  • Bardoxolone methyl shows promise as a treatment for kidney diseases.
  • Further investigation into its developmental activities is warranted.

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