Changes in effective optical zone after small-incision lenticule extraction in high myopia

To evaluate the four measurement approaches on the determination of effective optical zone (EOZ) using Scheimpflug tomography after small-incision lenticule extraction surgery in eyes with high myopia.

Corneal refractive surgery conducted in an eye hospital in southern China.

This is a retrospective cohort study.

In total, 74 subjects were recruited. EOZ was measured at 3 months postoperatively using vertex-based (EOZ_V), pupil-based (EOZ_P), 4 mm-ring-based total corneal refraction method (EOZ₄) and tangential curvature difference map method (EOZ_D), and their consistencies were compared. EOZs and planned optical zone (POZ) were compared and analyzed with eccentricity, ablation degree (AD) and total corneal aberrations.

At 3 months after surgery, the mean root mean square of ΔHOA, ΔComa, ΔTrefoil and ΔSA were 0.53 ± 0.27 μm, 0.36 ± 0.20 μm, 0.01 ± 0.84 μm and 0.16 ± 0.14 μm, respectively. EOZ_V, EOZ_P, EOZ₄ and EOZ_D were 5.87 ± 0.44 mm, 5.85 ± 0.45 mm, 4.78 ± 0.40 mm and 5.29 ± 0.27 mm, respectively, which were significantly smaller than POZ 6.48 ± 0.16 mm. Bland-Altman plots showed a good consistency among the four EOZs. The difference between the EOZ_V and EOZ_P was 0.02 mm within the range of clinically acceptable difference. In addition, the eccentricity was positively correlated with ΔHOA, ΔComa and ΔSA.

All 4 measurement approaches demonstrated the reduction of EOZs compared to POZ. The EOZ_V was the closest to POZ, followed by EOZ_P. The ΔEOZs showed no significant difference with eccentricity, AD and corneal aberrations.