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Related Concept Videos

Metal-Ligand Bonds02:51

Metal-Ligand Bonds

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The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
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Complexation Equilibria: Factors Influencing Stability of Complexes01:09

Complexation Equilibria: Factors Influencing Stability of Complexes

468
In complexation reactions, metal cations are the electron pair acceptors, and the ligands are the electron pair donors. The stability of the metal complexes depends primarily on the complexing ability of the central metal ion and the nature of the ligands. Generally, the complexing ability of the metal ion depends on the size and charge of the ion. As the metal ion size increases, the stability of the metal complexes decreases, provided that the valency of the metal ion and the ligands remain...
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Complexometric Titration: Ligands00:43

Complexometric Titration: Ligands

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Different monodentate and polydentate ligands are used as complexing agents in complexometric titration reactions. The formation of complexes by mono- and bidentate ligands involves two or more intermediate steps, limiting their use as complexing agents. In comparison, polydentate ligands can form complexes with metal ions in a single-step process, facilitating sharper end points. This means polydentate ligands, such as amino carboxylic acid derivatives, are most commonly employed in...
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Complexation Equilibria: The Chelate Effect01:19

Complexation Equilibria: The Chelate Effect

644
In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
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Harnessing Immunogenic PANoptosis With Iridium(III) Biradical Photosensitizers for Melanoma Photoimmunotherapy.

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A Deep-Red-Absorbing Osmium(II) Complex as a Photosensitizer for Photodynamic Therapy Inducing Immunogenic Cell Death.

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Correction to "Three in One: <i>In Vitro</i> and <i>In Vivo</i> Evaluation of Anticancer Activity of a Theranostic Agent that Combines Magnetic Resonance Imaging, Optical Bioimaging, and Photodynamic Therapy Capabilities".

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Detection and Recovery of Palladium, Gold and Cobalt Metals from the Urban Mine Using Novel Sensors/Adsorbents Designated with Nanoscale Wagon-wheel-shaped Pores
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Stimuli-Responsive Metal Complexes for Biomedical Applications.

Ivanna Amarsy1, Sébastien Papot2, Gilles Gasser1

  • 1Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, 75005, Paris, France.

Angewandte Chemie (International Ed. in English)
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Metal-based prodrugs offer solutions to toxicity and delivery issues in cancer therapy. By exploiting tumor-specific triggers, these compounds enhance drug targeting and efficacy, improving biomedical applications.

Keywords:
diagnostic toolsdrug releasemedicinal inorganic chemistrymetals in medicineselective delivery

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Area of Science:

  • Biomedical applications of metal-based compounds.
  • Drug delivery systems.
  • Oncology therapeutics.

Background:

  • Metal compounds offer unique therapeutic and diagnostic potential.
  • Challenges include toxicity, poor solubility, and biodistribution.
  • Metal-based prodrugs address these limitations.

Purpose of the Study:

  • To review advances in metal-based prodrugs for oncology.
  • To highlight the exploitation of tumor-associated stimuli for targeted drug delivery.

Main Methods:

  • Discussion of strategies for metal-based prodrug design.
  • Analysis of tumor-specific triggers (pH, redox, enzymes).
  • Review of recent developments in the field.

Main Results:

  • Metal-based prodrugs demonstrate potential for targeted cancer therapy.
  • Tumor-specific stimuli enable selective drug release.
  • Overcoming limitations of traditional metal-based drugs.

Conclusions:

  • Metal-based prodrugs represent a promising approach in oncology.
  • Targeted delivery via tumor stimuli enhances therapeutic outcomes.
  • Further development is crucial for clinical translation.