Related Experiment Video

Updated: Sep 6, 2025

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis
09:36

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis

Published on: August 12, 2025

58

Non-obstructive Plaque and Treatment of INOCA: More to Be Learned

Lina Ya'Qoub1, Islam Y Elgendy2, Carl J Pepine3

  • 1Division of Interventional Cardiology, Henry Ford Hospital, Detroit, MI, USA.

Current Atherosclerosis Reports
|July 5, 2022
PubMed

Insights

Ischemia with non-obstructive coronary artery disease (INOCA) affects many patients with chest pain. Stratified medical therapy shows promise in improving INOCA patient outcomes and quality of life.

Area of Science:

  • Cardiology
  • Internal Medicine

Background:

  • Ischemia with non-obstructive coronary artery disease (INOCA) is diagnosed in a significant number of patients presenting with chest pain.
  • INOCA is linked to a higher risk of major adverse cardiac events and poses a substantial burden on healthcare systems.

Purpose of the Study:

  • To review the current understanding of INOCA, including its definition, epidemiology, pathophysiology, and management.
  • To highlight recent findings and ongoing clinical trials investigating INOCA.

Main Methods:

  • Review of existing scientific literature and clinical trial data.
  • Discussion of findings from the CorMicA trial regarding stratified medical therapy for INOCA.

Main Results:

  • The CorMicA trial demonstrated that stratified medical therapy improves symptoms and quality of life in INOCA patients.
  • Ongoing trials like the WARRIOR trial are evaluating intensive medical therapy versus usual care for INOCA.

Conclusions:

  • While evidence on INOCA management is evolving, stratified medical therapy is a promising approach.
  • Further research and ongoing clinical trials are crucial for optimizing the care of patients with INOCA.
Abstract

Keywords:
AnginaIschemiaIschemia with non-obstructive coronary arteriesMicrovascular dysfunctionVasospastic angina

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