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Updated: Sep 6, 2025

Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice

Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice

Published on: October 27, 2014

Massive hypertriglyceridemia associated with paclitaxel; a case report.

Anojian Koneshamoorthy¹, Danielle Hulse¹, Chia Yuen Chong²

¹Department of Endocrinology and Diabetes, Western Health, Melbourne, Australia.

Gynecologic Oncology Reports

|July 5, 2022

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A patient developed extremely high triglyceride levels during paclitaxel chemotherapy for fallopian tube cancer. Doctors switched treatment, and triglyceride levels normalized, suggesting paclitaxel as the cause.

Area of Science:

Oncology
Pharmacology
Endocrinology

Background:

Adjuvant chemotherapy is standard for high-grade serous fallopian tube carcinoma.
Paclitaxel and carboplatin are commonly used agents in this regimen.
Hypertriglyceridemia is a potential, though less common, side effect of chemotherapy.

Observation:

A patient undergoing paclitaxel and carboplatin chemotherapy developed massive hypertriglyceridemia (12,488 mg/dL).
This level is the highest reported association with paclitaxel treatment.
The patient's triglyceride levels normalized after paclitaxel was discontinued and replaced with gemcitabine.

Findings:

Paclitaxel was identified as the likely causative agent for the severe hypertriglyceridemia.
The case highlights an extreme adverse drug reaction to paclitaxel.

Keywords:

Fallopian tube carcinoma Hypertriglyceridemia Paclitaxel

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Last Updated: Sep 6, 2025

Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice

Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice

Published on: October 27, 2014

Long-term Live-cell Imaging to Assess Cell Fate in Response to Paclitaxel

Long-term Live-cell Imaging to Assess Cell Fate in Response to Paclitaxel

Published on: May 14, 2018

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles

Published on: August 2, 2016

Discontinuation of paclitaxel led to resolution of hypertriglyceridemia.

Implications:

Serum lipid monitoring is crucial for patients receiving taxane chemotherapy, including paclitaxel.
Individuals with pre-existing risk factors like type 2 diabetes or dyslipidemia may be more susceptible.
This case underscores the importance of vigilant monitoring and prompt management of chemotherapy-induced metabolic complications.