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Severe cholestasis associated with methyltestosterone: a case report.

M R Lucey, R H Moseley

The American Journal of Gastroenterology

|May 1, 1987

Summary

Methyltestosterone administration caused severe jaundice and weight loss in a 62-year-old man. The patient

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Area of Science:

Hepatology
Toxicology
Endocrinology

Background:

Methyltestosterone is an anabolic-androgenic steroid used for testosterone replacement therapy.
Drug-induced liver injury (DILI) is a significant concern with certain medications, including anabolic steroids.
Cholestasis is a condition where bile flow is interrupted or reduced, leading to jaundice.

Observation:

A 62-year-old male presented with severe jaundice and significant weight loss.
The patient's symptoms were attributed to the administration of methyltestosterone.
Clinical presentation mimicked signs of an underlying malignancy.

Findings:

The case demonstrated unusually severe cholestasis, a hallmark of liver dysfunction.
Histopathological findings, though not detailed in the abstract, were consistent with severe drug-induced liver injury.
The severity of cholestasis and associated symptoms posed a diagnostic challenge.

Implications:

This case highlights the potential for severe hepatotoxicity from methyltestosterone, even at therapeutic doses.
It underscores the importance of considering drug-induced liver injury in patients presenting with severe cholestasis and unexplained weight loss.
Clinicians should maintain a high index of suspicion for methyltestosterone hepatotoxicity when evaluating patients with these symptoms.

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