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Aneurysmal wall enhancement and hemodynamics: pixel-level correlation between spatial distribution.

Mingzhu Fu1, Fei Peng2,3,4, Miaoqi Zhang1

  • 1Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China.

Quantitative Imaging in Medicine and Surgery
|July 5, 2022
PubMed
Summary
This summary is machine-generated.

Inflammation and hemodynamics are linked in intracranial aneurysms. Wall shear stress negatively correlated with aneurysm wall enhancement, while oscillatory shear index positively correlated, indicating inflammation presence.

Keywords:
Unruptured intracranial aneurysms (UIAs)aneurysmal wall enhancementhemodynamicsindividual-patient

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Area of Science:

  • Neurosurgery
  • Medical Imaging
  • Biomedical Engineering

Background:

  • Intracranial aneurysm rupture is linked to inflammation and hemodynamics.
  • Biomarkers of aneurysm wall enhancement (AWE) and hemodynamic parameters are key risk factors.

Purpose of the Study:

  • To investigate the relationship between aneurysm wall enhancement and hemodynamic parameters.
  • To analyze these risk factors from an individual patient perspective.

Main Methods:

  • Prospective cross-sectional study of 29 patients with unruptured intracranial aneurysms.
  • High-resolution magnetic resonance imaging (HR-MRI) for AWE quantification.
  • Four-dimensional flow MRI (4D-flow MRI) for hemodynamic parameters (WSS, OSI).

Main Results:

  • In aneurysms with AWE, wall shear stress (WSS) was negatively correlated with AWE.
  • Oscillatory shear index (OSI) was positively correlated with AWE in most cases (91.7%).
  • Aneurysms without AWE showed no correlation between hemodynamics and inflammation.

Conclusions:

  • Aneurysm wall enhancement is associated with specific hemodynamic patterns.
  • Negative WSS and positive OSI correlations suggest inflammation in intracranial aneurysms.
  • Hemodynamic analysis can help identify aneurysms with inflammation.