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Quantitative 3D In Silico Modeling q3DISM of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease
Published on: December 26, 2016
Microbiome Impact on Amyloidogenesis
Jofre Seira Curto1, Amat Surroca Lopez1, Maria Casals Sanchez1
1Self-organization in Biological Systems Lab, Department of Biochemistry and Molecular Biology, Biosciences Faculty, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.
Abstract:
Our life is closely linked to microorganisms, either through a parasitic or symbiotic relationship. The microbiome contains more than 1,000 different bacterial species and outnumbers human genes by 150 times. Worryingly, during the last 10 years, it has been observed a relationship between alterations in microbiota and neurodegeneration. Several publications support the hypothesis that amyloid structures formed by microorganisms may trigger host proteins aggregation. In this review, we collect pieces of evidence supporting that the crosstalk between human and microbiota amyloid proteins could be feasible and, probably, a more common event than expected before. The combination of their outnumbers, the long periods of time that stay in our bodies, and the widespread presence of amyloid proteins in the bacteria Domain outline a worrying scenario. However, the identification of the exact microorganisms and the mechanisms through with they can influence human disease also opens the door to developing a new and diverse set of therapeutic strategies.
Insights
Microbial amyloid proteins may interact with human proteins, potentially contributing to neurodegeneration. Understanding this microbiome-host crosstalk could lead to novel therapeutic strategies for neurological diseases.
Area of Science:
- Microbiology
- Neuroscience
- Biochemistry
Background:
- The human microbiome comprises over 1,000 bacterial species, significantly outnumbering human genes.
- Alterations in the gut microbiota have been increasingly linked to neurodegenerative diseases over the past decade.
- Emerging evidence suggests microbial amyloid structures may initiate host protein aggregation.
Purpose of the Study:
- To review existing evidence on the potential crosstalk between microbial and human amyloid proteins.
- To explore the implications of this interaction in the context of neurodegeneration.
- To highlight the therapeutic potential arising from understanding these mechanisms.
Main Methods:
- Literature review of studies investigating microbial and human amyloid formation.
- Analysis of research on the gut-brain axis and neuroinflammation.
- Synthesis of evidence linking microbial components to host proteinopathies.
Main Results:
- Evidence supports the feasibility of crosstalk between microbial and human amyloid proteins.
- Microbial amyloids are widespread and persist in the body, posing a potential risk.
- The sheer number and longevity of microbes amplify concerns regarding amyloid interactions.
Conclusions:
- The interaction between microbial and human amyloid proteins is a plausible and potentially common factor in neurodegeneration.
- Identifying specific microbes and their mechanisms is crucial for therapeutic development.
- Targeting microbiome-host amyloid interactions offers a promising avenue for novel neurodegenerative disease therapies.
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