Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Acute bacterial exacerbations in bronchitis and asthma.

The American Journal of Medicine

|April 27, 1987

Summary

Bacterial exacerbations in chronic bronchitis and asthma are common. Prompt recognition and 10-14 day antibiotic treatment for common bacteria like Hemophilus influenzae improve outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Effective delivery of particles with the HandiHaler dry powder inhalation system over a range of chronic obstructive pulmonary disease severity.

Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine·2001

Same author

Pharmacokinetic/pharmacodynamic predictors of time to clinical resolution in patients with acute bacterial exacerbations of chronic bronchitis treated with a fluoroquinolone.

International journal of antimicrobial agents·2000

Same author

Short-course moxifloxacin therapy for treatment of acute bacterial exacerbations of chronic bronchitis. The Bronchitis Study Group.

Respiratory medicine·2000

Same author

Valid information from sputum: don't throw out the baby with the bath water.

Chest·1999

Same author

Randomized, double-blind study of ciprofloxacin and cefuroxime axetil for treatment of acute bacterial exacerbations of chronic bronchitis. The Bronchitis Study Group.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1998

Same author

Efficacy of oral ciprofloxacin vs. clarithromycin for treatment of acute bacterial exacerbations of chronic bronchitis. The Bronchitis Study Group.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1998

Area of Science:

Pulmonary Medicine
Infectious Diseases
Microbiology

Background:

Symptomatic exacerbations are frequent in chronic bronchitis and asthma management.
Identifying bacterial causes requires clinical symptoms, bronchial flora, and neutrophilic response.
Common pathogens include Hemophilus influenzae, Streptococcus pneumoniae, and Branhamella catarrhalis.

Purpose of the Study:

To outline the diagnostic criteria for bacterial exacerbations in chronic bronchitis and asthma.
To review effective antimicrobial treatments and their duration.
To highlight the need for new antimicrobial agents due to emerging resistance.

Main Methods:

Review of clinical symptoms for bacterial etiology.
Documentation of bronchial bacterial flora and neutrophilic inflammation.
Evaluation of treatment success with ampicillins, tetracyclines, or trimethoprim/sulfamethoxazole.

Main Results:

Ampicillin, synthetic tetracyclines, or trimethoprim/sulfamethoxazole are successful in 80-90% of bacterial exacerbations.
Emergence of resistant Hemophilus and pneumococci necessitates new drug development.
A minimum 10-14 day antimicrobial therapy duration increases the infection-free period.

Conclusions:

Prompt recognition of bacterial infection is crucial for appropriate treatment.
Extended antimicrobial therapy improves outcomes and prolongs the time between exacerbations.
Monitoring symptom resolution, reduced sputum flora, and decreased neutrophilic inflammation confirms adequate response.

Related Experiment Videos