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Related Concept Videos

Imaging Studies for Cardiovascular System III: X-Ray01:20

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The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
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Related Experiment Video

Updated: Sep 5, 2025

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Deep Learning for Detection of Exercise-Induced Pulmonary Hypertension Using Chest X-Ray Images.

Kenya Kusunose1, Yukina Hirata2, Natsumi Yamaguchi2

  • 1Department of Cardiovascular Medicine, Tokushima University Hospital, Tokushima, Japan.

Frontiers in Cardiovascular Medicine
|July 5, 2022
PubMed
Summary

A deep learning model using chest X-rays can help detect exercise-induced pulmonary hypertension (EIPH). This AI approach shows potential for clinical use, improving upon traditional methods for identifying EIPH in patients.

Keywords:
artificial intelligenceconnective tissue diseaseechocardiographyexercise pulmonary hypertensionscleroderma (SSc)

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Area of Science:

  • Cardiology
  • Pulmonary Medicine
  • Artificial Intelligence in Medicine

Background:

  • Stress echocardiography is a key tool for detecting exercise-induced pulmonary hypertension (EIPH).
  • Availability of stress echocardiography is limited by cost and equipment constraints.
  • Developing alternative, accessible methods for EIPH detection is crucial.

Purpose of the Study:

  • To evaluate a deep learning (DL) model utilizing chest X-rays (CXRs) for predicting EIPH during 6-minute walk stress echocardiography.
  • To assess the efficacy of an AI-driven approach in identifying EIPH in patients with connective tissue diseases.

Main Methods:

  • 142 patients with scleroderma or related conditions underwent 6-minute walk stress echocardiography.
  • EIPH was defined by abnormal cardiac output responses and elevated mean pulmonary artery pressure (mPAP).
  • A pre-existing AI model was used to predict pulmonary hypertension (PH) probability.

Main Results:

  • EIPH was identified in 52 patients, with higher resting mPAP compared to non-EIPH patients (n=90).
  • The DL model demonstrated a significantly higher PH probability in patients with EIPH.
  • The DL model improved prediction accuracy (AUC from 0.65 to 0.74) when added to baseline parameters.

Conclusions:

  • A DL model based on CXRs shows promise for detecting EIPH in clinical settings.
  • This AI approach offers a potential non-invasive method for EIPH screening.
  • Further validation could integrate CXR-based AI into routine patient assessment for EIPH.