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Related Concept Videos

Major Somatic Sensory Pathways01:28

Major Somatic Sensory Pathways

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Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
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Nociception01:44

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Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
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Overview of Somatic Sensory Pathways01:29

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Somatic sensory or somatosensory pathways refer to the neural pathways that carry information related to touch, pressure, pain, temperature, and proprioception from the skin, muscles, tendons, and joints to the brain. These pathways involve several stages of processing and integration of sensory information.
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The dorsal...
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Spinal Cord: Information Processing01:10

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The spinal cord is an integral hub for motor and sensory information that enables the brain to communicate with the peripheral nervous system (PNS). This communication consists of relaying sensory data and transmission of motor commands.
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Sensory information processing begins at the sensory receptors located in the skin and other tissues, which detect somatic sensory stimuli such as touch, temperature, or pain. These receptors function as catalysts, initiating...
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Analgesia and Pain Management01:25

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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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Related Experiment Video

Updated: Sep 5, 2025

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
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Complement Receptor 3 Pathway and NMDA Receptor 2B Subunit Involve Neuropathic Pain Associated with Spinal Cord

Yong Li1, Sheng-Chun Fang2, Lan Zhou1

  • 1College of Biotechnology, Guilin Medical University, Guilin, Guangxi, 541100, People's Republic of China.

Journal of Pain Research
|July 5, 2022
PubMed
Summary

Spinal cord injury (SCI) can cause neuropathic pain (NP) in some individuals. This study found that the complement receptor 3/complement component 3 (CR3/C3) pathway and NMDA receptor subunit 2B (NR2B) are involved in SCI-evoked NP.

Keywords:
NMDA receptor 2B subunitcomplement component 3complement receptor 3neuropathic painspinal cord injury

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Area of Science:

  • Neuroscience
  • Immunology
  • Pain Research

Background:

  • Neuropathic pain (NP) following spinal cord injury (SCI) is a significant clinical challenge with poorly understood mechanisms.
  • The complement system and NMDA receptor subunit 2B (NR2B) are implicated in SCI pathophysiology and NP development.
  • NP affects only a subset of SCI patients, highlighting the need to identify contributing factors.

Purpose of the Study:

  • To investigate the correlation between the complement receptor 3/complement component 3 (CR3/C3) pathway and NR2B expression in SCI-evoked NP.
  • To explore potential molecular mechanisms underlying SCI-evoked NP.

Main Methods:

  • Established a trauma-induced SCI rat model and assessed NP through behavioral analysis.
  • Utilized transcriptome analysis to identify CR3/C3 pathway genes related to synaptic modification.
  • Examined NR2B expression and distribution in the injured spinal cord using immunohistochemical analysis.

Main Results:

  • Neuropathic pain developed in 52.9% of SCI rats.
  • C3 mRNA levels were decreased in NP rats and increased in non-NP rats; C1q and CR3 mRNA were increased in all SCI rats, but higher in non-NP rats.
  • NR2B mRNA and NR2B-positive cells were significantly elevated in SCI-evoked NP rats, particularly in the superficial dorsal horn.

Conclusions:

  • Neuropathic pain in SCI is associated with specific alterations in the CR3/C3 pathway and NR2B expression.
  • These findings suggest the involvement of CR3/C3 and NR2B in the development and maintenance of SCI-evoked NP.
  • Further research is warranted to elucidate the precise mechanisms linking CR3/C3, NR2B, and SCI-evoked NP.