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Melatonin and Sleep Disturbances in Children With Atopic Dermatitis

Reiva Farah Dwiyana1, Lita Nuraeni1, Inne Arline Diana1

  • 1Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran-Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia.

Clinical, Cosmetic and Investigational Dermatology
|July 5, 2022
PubMed

Insights

Children with atopic dermatitis (AD) experience poorer sleep quality and lower melatonin levels. However, melatonin levels do not directly correlate with sleep disturbances in moderate AD cases.

Area of Science:

  • Pediatric Dermatology
  • Sleep Medicine
  • Endocrinology

Background:

  • Atopic dermatitis (AD) is a common inflammatory skin condition in children.
  • Sleep disturbances are frequently reported in children with AD, impacting their quality of life.
  • The role of melatonin in sleep regulation and its potential association with AD-related sleep issues require further investigation.

Purpose of the Study:

  • To investigate the correlation between melatonin levels and sleep quality in children with moderate atopic dermatitis.
  • To compare melatonin levels and sleep quality, assessed by the Children's Sleep Habit Questionnaire (CSHQ), between children with and without AD.

Main Methods:

  • An analytic study with a cross-sectional design was conducted.
  • Participants included 19 children with moderate AD (case group) and 19 healthy children (control group).
  • Melatonin levels and CSHQ scores were measured and compared between groups; correlation analyses were performed.

Main Results:

  • Children with moderate AD exhibited significantly higher CSHQ scores (indicating poorer sleep quality) and lower melatonin levels compared to controls.
  • A significant correlation was found between the Severity of Atopic Dermatitis (SCORAD) and CSHQ scores.
  • No significant correlation was observed between melatonin levels and CSHQ scores, nor between melatonin levels and SCORAD.

Conclusions:

  • Children with moderate AD experience impaired sleep quality and reduced melatonin levels.
  • Melatonin levels do not appear to be the primary driver of sleep disturbances in this population.
  • Sleep quality in moderate AD is strongly associated with disease severity (SCORAD), not directly with melatonin levels.
Abstract

Keywords:
CSHQSCORADatopic dermatitismelatonin

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