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Impaired Sensitivity to Thyroid Hormones Is Associated With Elevated Blood Glucose in Coronary Heart Disease

Lu Yu1, Zhu Li1, Rongrong Yang1

  • 1Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Frontiers in Endocrinology
|July 5, 2022
PubMed

Insights

Thyroid hormone sensitivity is linked to elevated blood glucose (EBG) in coronary heart disease (CHD) patients. Lower sensitivity correlates with higher EBG risk, particularly in females and older adults.

Area of Science:

  • Endocrinology
  • Cardiology
  • Metabolic Health

Background:

  • Thyroid hormones play a crucial role in glucose homeostasis.
  • The relationship between thyroid hormone sensitivity and elevated blood glucose (EBG) in patients with coronary heart disease (CHD) is not well understood.
  • Understanding this association is vital for managing cardiovascular and metabolic health.

Purpose of the Study:

  • To investigate the association between thyroid hormone sensitivity and the risk of EBG in patients with CHD.
  • To explore how this association differs between sexes and age groups.

Main Methods:

  • A large multicenter retrospective study of 30,244 CHD patients (aged 30-80 years).
  • Calculation of central thyroid hormone sensitivity indices (TFQI, TSHI, TT4RI, PTFQI) and peripheral sensitivity (FT3/FT4 ratio).
  • Logistic regression analysis was used to determine the relationship between thyroid hormone sensitivity and EBG, with normal glucose tolerance as reference.

Main Results:

  • Elevated blood glucose (EBG) was present in 51.23% of participants.
  • Increased risk of EBG was negatively correlated with central thyroid hormone sensitivity indices (TSHI, TT4RI, TFQI, PTFQI).
  • Higher EBG risk was positively associated with peripheral sensitivity (FT3/FT4 ratio), with greater risk observed in males and younger patients (<60 years).

Conclusions:

  • Thyroid hormone sensitivity is significantly associated with EBG in CHD patients.
  • The association between thyroid hormone sensitivity and EBG is more pronounced in females compared to males.
  • Older patients (over 60 years) exhibit a stronger association between thyroid hormone sensitivity and EBG risk than younger patients.
Abstract

Keywords:
coronary heart diseasediabeteselevated blood glucoseprediabetesresistance to thyroid hormonesthyroid hormone sensitivity

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