Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Long-term Depression01:03

Long-term Depression

2.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
2.6K
Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

507
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
507
Long-term Potentiation01:25

Long-term Potentiation

2.9K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
2.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Therapeutic Potential of Leptin in Neurodegenerative Disease.

Biomedicines·2025
Same author

Novel Leptin-Based Therapeutic Strategies to Limit Synaptic Dysfunction in Alzheimer's Disease.

International journal of molecular sciences·2024
Same author

Leptin prevents aberrant targeting of tau to hippocampal synapses via PI 3 kinase driven inhibition of GSK3β.

Journal of neurochemistry·2023
Same author

G-protein coupled estrogen receptor (GPER1) activation promotes synaptic insertion of AMPA receptors and induction of chemical LTP at hippocampal temporoammonic-CA1 synapses.

Molecular brain·2023
Same author

Leptin-based hexamers facilitate memory and prevent amyloid-driven AMPA receptor internalisation and neuronal degeneration.

Journal of neurochemistry·2022
Same author

Leptin regulation of synaptic function at hippocampal TA-CA1 and SC-CA1 synapses.

Vitamins and hormones·2022

Related Experiment Video

Updated: Sep 5, 2025

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

12.7K

Food for Thought: Leptin and Hippocampal Synaptic Function.

Jenni Harvey1

  • 1Division of Systems Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom.

Frontiers in Pharmacology
|July 5, 2022
PubMed
Summary
This summary is machine-generated.

Leptin, a hormone controlling energy balance, also impacts brain function. Recent research highlights its role at hippocampal synapses, influencing learning, memory, and brain health.

Keywords:
AMPA receptorNMDA Rhippocampus (CA1)leptinsynaptic plasiticity

More Related Videos

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
14:57

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Published on: March 23, 2011

94.4K
Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents
11:29

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents

Published on: September 4, 2015

14.1K

Related Experiment Videos

Last Updated: Sep 5, 2025

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

12.7K
Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
14:57

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Published on: March 23, 2011

94.4K
Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents
11:29

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents

Published on: September 4, 2015

14.1K

Area of Science:

  • Neuroendocrinology
  • Cognitive Neuroscience
  • Synaptic Plasticity

Background:

  • Leptin is a key endocrine hormone regulating energy homeostasis via hypothalamic signals.
  • The hippocampus is increasingly recognized as a critical brain target for leptin's central actions.
  • Leptin receptors are highly localized to hippocampal synapses, suggesting a direct role in neuronal function.

Purpose of the Study:

  • To review recent findings on leptin's actions at hippocampal synapses.
  • To explore the impact of leptin on cognitive processes, particularly learning and memory.
  • To discuss the implications of leptin's hippocampal activity for brain health and disease.

Main Methods:

  • Review of current scientific literature on leptin and the hippocampus.
  • Analysis of studies investigating leptin receptor localization and activation.
  • Synthesis of evidence linking leptin signaling to cognitive functions.

Main Results:

  • Leptin significantly influences hippocampal synaptic function.
  • Activation of hippocampal leptin receptors modulates learning and memory processes.
  • Dysregulation of leptin signaling may contribute to neurological disorders.

Conclusions:

  • Leptin plays a crucial role in hippocampal synaptic plasticity and cognitive function.
  • Targeting leptin pathways in the hippocampus may offer therapeutic strategies for brain diseases.
  • Further research is needed to fully elucidate leptin's complex role in the brain.