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Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain,...
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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Revisiting the Tenascins: Exploitable as Cancer Targets?

Richard P Tucker1, Martin Degen2

  • 1Department of Cell Biology and Human Anatomy, University of California, Davis, Davis, CA, United States.

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|July 5, 2022
PubMed
Summary
This summary is machine-generated.

Tumor microenvironment supports cancer growth. Tenascins, particularly tenascin-C and tenascin-W, are promising targets for anti-cancer therapies due to their tumor-specific expression.

Keywords:
anti-cancer therapybiomarkerextracellular matrixtenascinstumor stroma

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Area of Science:

  • Oncology
  • Extracellular Matrix Biology
  • Cancer Therapeutics

Background:

  • Tumors rely on the tumor microenvironment (TME), including extracellular matrix (ECM) and host cells, for progression.
  • The TME creates a unique, tumor-permissive niche distinct from normal physiological conditions.
  • The TME's composition offers potential therapeutic targets for anti-cancer strategies.

Purpose of the Study:

  • To review the expression of all four tenascin family members in tumors.
  • To focus on tenascin-C and tenascin-W as promising diagnostic and therapeutic targets.
  • To discuss their oncogenic functions and potential in anti-cancer treatment.

Main Methods:

  • Literature review of tenascin expression in tumors.
  • Analysis of oncogenic functions of tenascin-C and tenascin-W.
  • Evaluation of their potential as diagnostic and targetable molecules.

Main Results:

  • All four tenascin family members are expressed in the ECM surrounding cancer cells.
  • Tenascin-C and tenascin-W show high expression in tumor stroma with low abundance in healthy tissues.
  • These molecules exhibit oncogenic functions and hold potential for clinical applications.

Conclusions:

  • Tenascin-C and tenascin-W are key components of the tumor microenvironment.
  • Their tumor-specific expression and oncogenic roles make them valuable targets for novel anti-cancer therapies.
  • Targeting tenascins could lead to improved cancer treatment outcomes.