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High-Throughput, Multi-Image Cryohistology of Mineralized Tissues

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Published on: September 14, 2016

Technical and Diagnostic Issues in Whole Slide Imaging Published Validation Studies.

Paola Chiara Rizzo¹, Ilaria Girolami², Stefano Marletta^1,3

¹Department of Pathology and Diagnostics and Public Health, Section of Pathology, University Hospital of Verona, Verona, Italy.

Frontiers in Oncology

|July 5, 2022

Summary

Digital pathology using whole-slide imaging (WSI) faces adoption hurdles due to technical and diagnostic pitfalls. Addressing pre-scanning quality and pathologist training is crucial for reliable clinical use.

Keywords:

artificial intelligence digital pathology systematic (literature) reviews validation study whole slide imaging

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Area of Science:

Pathology
Medical Imaging
Digital Health

Background:

Whole-slide imaging (WSI) offers potential in digital pathology but faces slow adoption for primary diagnosis.
Validation studies reveal persistent technical and diagnostic challenges hindering widespread clinical implementation.

Approach:

A systematic literature search identified 45 validation studies on WSI feasibility for diagnostic pathology.
Technical and diagnostic issues encountered in these studies were meticulously recorded and analyzed.

Key Points:

Common technical problems include slide scan failures, extended review times, and resolution requirements.
Diagnostic challenges involve grading dysplasia, assessing mitoses, identifying microorganisms, and defining tumor invasive fronts.
Nearly half of the studies reported both technical and diagnostic issues.

Conclusions:

Despite technological progress, critical concerns regarding WSI reliability for clinical diagnosis persist.
Improving pre-scanning quality and pathologist training can mitigate technical difficulties.
WSI may amplify existing diagnostic challenges for pathologists.