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Nucleic Acid-Scavenging Hydrogels Accelerate Diabetic Wound Healing
Hai Zhong1, Huiyi Liang1, Yanzi Yan1
1School of Materials Science and Engineering, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Sun Yat-sen University, Guangzhou 510006, China.
Biomacromolecules
|July 5, 2022
Summary
Cationic hydrogels effectively reduce cell-free DNA (cfDNA) and inflammation in diabetic foot ulcers (DFU). This promotes wound healing without toxicity, offering a new treatment approach for DFU.
Area of Science:
- Biomaterials Science
- Wound Healing
- Inflammation Research
Background:
- Chronic inflammation and high cell-free nucleic acid (cfDNA) levels impede healing in diabetic foot ulcers (DFU).
- cfDNA is increasingly recognized for its role in promoting inflammation.
Purpose of the Study:
- To investigate the efficacy of polyacrylamide-based cationic hydrogels in managing inflammation and promoting healing in a diabetic rat model of DFU.
- To assess the impact of hydrogel application on cfDNA levels and inflammatory markers in DFU wounds.
Main Methods:
- Fabrication of polyacrylamide-based cationic hydrogels.
- Topical application of hydrogels to diabetic rat model ulcers.
- Quantification of cfDNA levels in the wound area.
- Assessment of inflammation levels.
- Monitoring of wound closure rates.
- Evaluation of systemic toxicity.
Main Results:
- Hydrogel treatment significantly reduced cfDNA levels in the DFU wound area.
- A marked decrease in inflammation was observed following hydrogel application.
- Significant promotion of wound closure was achieved.
- No systemic toxicity was detected.
Conclusions:
- Polyacrylamide-based cationic hydrogels are effective in adsorbing cfDNA, thereby reducing inflammation in DFU.
- These hydrogels represent a promising therapeutic strategy for treating refractory DFU by mitigating inflammation and enhancing wound healing.
- The developed hydrogels offer a safe and effective approach to combatting inflammation in DFU.
