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Updated: Sep 5, 2025
05:53
Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
Published on: July 24, 2013
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Managing frailty in people with human immunodeficiency virus
Clare Bristow1, Tristan Barber2
1Department of HIV Medicine, Royal Free London NHS Foundation Trust, London, UK.
Summary
Frailty is a growing concern for the aging population with human immunodeficiency virus (HIV). Exercise and optimizing comorbidities are key interventions to manage frailty in people with HIV.
Area of Science:
- Gerontology
- Infectious Diseases
- Public Health
Background:
- The aging population with human immunodeficiency virus (HIV) experiences a higher prevalence of frailty at younger ages.
- Frailty in people with HIV is linked to increased multimorbidity, disability, and mortality.
- Non-acquired immune deficiency syndrome (AIDS)-related conditions contribute significantly to morbidity and mortality in this demographic.
Discussion:
- This article reviews interventions to mitigate frailty progression in people living with HIV.
- A multidisciplinary, holistic approach is crucial for managing this complex patient group.
- Case studies illustrate the practical application of these interventions.
Key Insights:
- Exercise, particularly group-based physiotherapy, is the most effective intervention against functional decline and frailty symptoms.
- Optimizing medical and psychiatric comorbidities, including appropriate deprescribing, is essential.
- Addressing social determinants like isolation and loneliness can be beneficial but relies on community resources.
Outlook:
- Further research is needed to evaluate pharmacological and nutritional interventions for frailty.
- A deeper understanding of frailty's pathophysiology in people with HIV is required.
- Developing targeted interventions necessitates continued investigation into the unique aspects of frailty within this population.
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