Related Experiment Video

Updated: Sep 5, 2025

Author Spotlight: Accelerating Research on Bacterial Extracellular Vesicles Separation and Heterogeneity
06:39

Author Spotlight: Accelerating Research on Bacterial Extracellular Vesicles Separation and Heterogeneity

Published on: September 1, 2023

3.0K

Intestinal microbiota-derived membrane vesicles and their role in chronic kidney disease

Qin Yi Wu1, Bi Cheng Liu1, Xiong Zhong Ruan2

  • 1Institute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.

Biochimica Et Biophysica Acta. Molecular Basis of Disease
|July 5, 2022
PubMed

Insights

Intestinal microbiota-derived membrane vesicles (MVs) are crucial for gut health. This review explores their role in chronic kidney disease (CKD), offering insights for diagnosis and treatment.

Area of Science:

  • Microbiology
  • Immunology
  • Nephrology

Background:

  • Intestinal microbiota-derived membrane vesicles (MVs) are vital for gut immunity and ecosystem balance.
  • The specific role of MVs in chronic kidney disease (CKD) pathogenesis is not well understood.

Purpose of the Study:

  • To review the structure and function of various MVs.
  • To summarize potential pathogenic mechanisms of MVs in CKD.
  • To highlight the clinical significance of MVs in CKD diagnosis and treatment.

Main Methods:

  • Literature review of studies on MVs and CKD.
  • Analysis of MV structure and biological functions.
  • Synthesis of evidence on MV-mediated pathogenic mechanisms.

Main Results:

  • MVs possess diverse structures and functions impacting host physiology.
  • Several potential mechanisms link MVs to CKD progression.
  • Understanding these mechanisms could aid CKD management.

Conclusions:

  • MVs represent a significant factor in the gut-kidney axis.
  • Further research into MVs could lead to novel diagnostic and therapeutic strategies for CKD.
  • MVs may serve as important biomarkers or therapeutic targets in chronic kidney disease.
Keywords:
Chronic kidney diseaseIntestinal microbiotaIntestinal microbiota-derived membrane vesicle

More Related Videos

Separation and Differential Characterization of Gut Microbial Extracellular Vesicles in Salt-Sensitive Rats under High-Salt Diet Conditions07:21

Separation and Differential Characterization of Gut Microbial Extracellular Vesicles in Salt-Sensitive Rats under High-Salt Diet Conditions

Published on: June 6, 2025

299
Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection10:15

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection

Published on: November 10, 2021

1.9K

Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
80
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
64
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
76
Microvilli00:55

Microvilli

Microvilli are tiny finger-like projections found on the surface of certain cells. Their purpose is to increase the surface area of the cell's apical surface, resulting in more effective absorption or secretion of substances.
These microvilli are predominantly present in cells lining the small intestine, kidney tubules, and certain cells in the respiratory and reproductive systems. By significantly expanding the surface area of the cell membrane, microvilli enhance the cell's capacity...
6.9K
Intralumenal Vesicles and Multivesicular Bodies01:38

Intralumenal Vesicles and Multivesicular Bodies

Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
3.7K
Overview of Exosomes01:36

Overview of Exosomes

Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
2.8K