Related Experiment Video
Updated: Sep 5, 2025

Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization
Published on: December 23, 2020
Functional mutations of SARS-CoV-2: implications to viral transmission, pathogenicity and immune escape
Shengyuan Dang1,2, Lili Ren1,2, Jianwei Wang1,2
1National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
Abstract:
The pandemic of coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to major public health challenges globally. The increasing viral lineages identified indicate that the SARS-CoV-2 genome is evolving at a rapid rate. Viral genomic mutations may cause antigenic drift or shift, which are important ways by which SARS-CoV-2 escapes the human immune system and changes its transmissibility and virulence. Herein, we summarize the functional mutations in SARS-CoV-2 genomes to characterize its adaptive evolution to inform the development of vaccination, treatment as well as control and intervention measures.
More Related Videos
Related Concept Videos
Viral Mutations
Mutations in Microorganisms
Mutations
Leaky Scanning
Single Nucleotide Polymorphisms-SNPs
Viruses with RNA Genomes

