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Updated: Sep 5, 2025

Monitoring Stub1-Mediated Pexophagy
Published on: May 12, 2023
The peroxisome: an up-and-coming organelle in immunometabolism
Francesca Di Cara1, Stéphane Savary2, Werner J Kovacs3
1Dalhousie University, Department of Microbiology and Immunology, Halifax, NS B3K 6R8, Canada.
Abstract:
Peroxisomes are essential metabolic organelles, well known for their roles in the metabolism of complex lipids and reactive ionic species. In the past 10 years, peroxisomes have also been cast as central regulators of immunity. Lipid metabolites of peroxisomes, such as polyunsaturated fatty acids (PUFAs), are precursors for important immune mediators, including leukotrienes (LTs) and resolvins. Peroxisomal redox metabolism modulates cellular immune signaling such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activation. Additionally, peroxisomal β-oxidation and ether lipid synthesis control the development and aspects of the activation of both innate and adaptive immune cells. Finally, peroxisome number and metabolic activity have been linked to inflammatory diseases. These discoveries have opened avenues of investigation aimed at targeting peroxisomes for therapeutic intervention in immune disorders, inflammation, and cancer.
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