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Updated: Sep 5, 2025
Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
Published on: March 15, 2024
The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease
Xuexian Fang1,2,3, Hossein Ardehali4, Junxia Min5
1Department of Nutrition and Toxicology, School of Public Health, State Key Laboratory of Experimental Hematology, Hangzhou Normal University, Hangzhou, China.
Insights
Iron imbalance and ferroptosis are key factors in cardiovascular diseases. Understanding these processes in heart cells may lead to new treatments for conditions like heart failure and atherosclerosis.
Area of Science:
- Cardiology
- Cellular Biology
- Biochemistry
Background:
- Iron homeostasis is critical for heart function.
- Iron imbalance is linked to various cardiovascular diseases.
- Ferroptosis, an iron-dependent cell death, plays a role in cardiovascular pathology.
Purpose of the Study:
- To review the role of iron metabolism and ferroptosis in cardiovascular disease.
- To explore potential therapeutic targets for cardiovascular conditions.
- To discuss future directions in ferroptosis-targeted cardiovascular treatments.
Main Methods:
- Literature review of studies on iron metabolism and ferroptosis in cardiovascular disease.
- Analysis of molecular and metabolic pathways involved.
- Discussion of current research and clinical implications.
Main Results:
- Ferroptosis is implicated in atherosclerosis, heart failure, ischemia-reperfusion injury, and diabetic cardiomyopathy.
- Dysregulation of iron metabolism is a common factor in these conditions.
- Targeting ferroptosis presents a novel therapeutic strategy for cardiovascular diseases.
Conclusions:
- Understanding iron regulation and ferroptosis is crucial for managing cardiovascular diseases.
- Targeting ferroptosis pathways offers promising therapeutic avenues.
- Further research is needed to translate these findings into clinical practice.
Abstract:
The maintenance of iron homeostasis is essential for proper cardiac function. A growing body of evidence suggests that iron imbalance is the common denominator in many subtypes of cardiovascular disease. In the past 10 years, ferroptosis, an iron-dependent form of regulated cell death, has become increasingly recognized as an important process that mediates the pathogenesis and progression of numerous cardiovascular diseases, including atherosclerosis, drug-induced heart failure, myocardial ischaemia-reperfusion injury, sepsis-induced cardiomyopathy, arrhythmia and diabetic cardiomyopathy. Therefore, a thorough understanding of the mechanisms involved in the regulation of iron metabolism and ferroptosis in cardiomyocytes might lead to improvements in disease management. In this Review, we summarize the relationship between the metabolic and molecular pathways of iron signalling and ferroptosis in the context of cardiovascular disease. We also discuss the potential targets of ferroptosis in the treatment of cardiovascular disease and describe the current limitations and future directions of these novel treatment targets.
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