Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

DNA Packaging00:58

DNA Packaging

103.5K
Overview
103.5K
Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

47.6K
Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
47.6K
DNA as a Genetic Template02:05

DNA as a Genetic Template

22.6K
Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
22.6K
DNA Microarrays02:34

DNA Microarrays

18.4K
Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
18.4K
Chromatin Packaging01:32

Chromatin Packaging

17.0K
Each human somatic cell contains 6 billion base pairs of DNA. Each base pair is 0.34 nm long, meaning each diploid cell contains a staggering 2 meters of DNA. This long DNA strand is packed inside a nucleus measuring only 10-20 microns in diameter with the help of specialized DNA-binding proteins called histones. Together they form a compact DNA-protein complex called chromatin. The chromatin is further compacted into higher-order structures. The highest level of compaction is achieved during...
17.0K
The Nucleosome01:19

The Nucleosome

2.1K
Human DNA is almost two meters long. However, it is compressed inside a tiny nucleus measuring only a few microns in diameter. To make this degree of compaction possible, DNA is organized into several sequential levels so that it can fit into such a tiny space. The most compact form of DNA is a chromosome that can be seen under a microscope in a dividing cell.
In a chromosome, DNA is wound twice around a protein complex called a histone octamer core, which consists of 8 histone proteins. This...
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Mechanism of Mudan Granules in protecting podocytes and improving diabetic nephropathy by regulating PPARγ/FABP4 axis].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·2026
Same author

Effect of intrinsic alkali (earth) metals on hydrothermal conversion of lignocellulosic biomass.

Bioresource technology·2026
Same author

Xylene exposure, miR-181b-5p and miR-106b-5p alterations, and type 2 diabetes mellitus: Exploring relationship, mediation, and mechanism.

Ecotoxicology and environmental safety·2026
Same author

Combining radiotherapy with CAR-T cell therapy for solid tumors: Challenges, mechanisms, and future directions.

Precision radiation oncology·2026
Same author

An Expanded T2-FLAIR Mismatch Phenotype in IDH-Mutant Astrocytomas.

Journal of magnetic resonance imaging : JMRI·2026
Same author

Seasonal and Species-Specific Variations in Gut Microbiota of Wild Ungulates in Captivity.

Animals : an open access journal from MDPI·2026
Same journal

Modeling single nucleus microglia across species identifies immune pathways and therapeutic candidates in Alzheimer's disease.

NPJ systems biology and applications·2026
Same journal

Metabolic set theory: a generalized model of microbial interactions.

NPJ systems biology and applications·2026
Same journal

Gene prioritization across ancestries uncovers distinct molecular pathophysiology and therapeutic landscape in polycystic ovary syndrome.

NPJ systems biology and applications·2026
Same journal

A mathematical model of folate-mediated one-carbon metabolism in Down syndrome.

NPJ systems biology and applications·2026
Same journal

A minimal mechanically consistent model of smoothly dividing disk-shaped cells.

NPJ systems biology and applications·2026
Same journal

Virtual twins and the future of human developmental biology.

NPJ systems biology and applications·2026
See all related articles

Related Experiment Video

Updated: Sep 5, 2025

High-Density DNA and RNA microarrays - Photolithographic Synthesis, Hybridization and Preparation of Large Nucleic Acid Libraries
11:22

High-Density DNA and RNA microarrays - Photolithographic Synthesis, Hybridization and Preparation of Large Nucleic Acid Libraries

Published on: August 12, 2019

18.2K

Adaptive coding for DNA storage with high storage density and low coverage.

Ben Cao1, Xiaokang Zhang1, Shuang Cui1

  • 1School of Computer Science and Technology, Dalian University of Technology, 116024, Dalian, China.

NPJ Systems Biology and Applications
|July 5, 2022
PubMed
Summary
This summary is machine-generated.

This study introduces an adaptive coding DNA storage system to overcome limitations in DNA data storage. The new system enhances storage density and reduces read coverage for efficient data archiving.

More Related Videos

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
09:26

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

4.3K
Ultra-long Read Sequencing for Whole Genomic DNA Analysis
10:34

Ultra-long Read Sequencing for Whole Genomic DNA Analysis

Published on: March 15, 2019

23.0K

Related Experiment Videos

Last Updated: Sep 5, 2025

High-Density DNA and RNA microarrays - Photolithographic Synthesis, Hybridization and Preparation of Large Nucleic Acid Libraries
11:22

High-Density DNA and RNA microarrays - Photolithographic Synthesis, Hybridization and Preparation of Large Nucleic Acid Libraries

Published on: August 12, 2019

18.2K
DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
09:26

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

4.3K
Ultra-long Read Sequencing for Whole Genomic DNA Analysis
10:34

Ultra-long Read Sequencing for Whole Genomic DNA Analysis

Published on: March 15, 2019

23.0K

Area of Science:

  • Biotechnology
  • Data Storage
  • Bioinformatics

Background:

  • Information technology advancements generate vast data, necessitating novel storage solutions.
  • DNA offers high density, durability, and longevity for data storage but faces challenges like low space utilization and high read coverage.
  • Current DNA storage methods require optimization for efficient data encoding and retrieval.

Purpose of the Study:

  • To propose an adaptive coding DNA storage system to address current limitations.
  • To optimize DNA data storage at a system level using adaptive coding strategies.
  • To enhance storage density and reduce read coverage in DNA-based data archiving.

Main Methods:

  • Developed an adaptive coding system employing varied coding schemes for different DNA strand regions.
  • Implemented adaptive generation of coding constraint thresholds for system-level optimization.
  • Stored and retrieved image, video, and PDF files using the adaptive coding DNA storage approach.

Main Results:

  • Successfully stored 698 KB of diverse data (images, video, PDF) in DNA using adaptive coding.
  • Sequenced and losslessly decoded the DNA-stored data back into raw format.
  • Achieved higher storage density and lower read coverage compared to previous DNA storage methods.

Conclusions:

  • The proposed adaptive coding DNA storage system significantly improves efficiency.
  • This advancement promotes the development of practical and scalable carbon-based storage solutions.
  • Adaptive coding is a key strategy for overcoming current challenges in DNA data storage.