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Related Experiment Video

Updated: Sep 5, 2025

Isolation of Sertoli Cells and Peritubular Cells from Rat Testes
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Exploring Nrf2 as a therapeutic target in testicular dysfunction.

Damilare E Rotimi1,2, Oluwafemi A Ojo3,4, Tomilola D Olaolu5,3

  • 1SDG 03 Group - Good Health & Well-being, Landmark University, Kwara State, Omu-Aran, 251101, Nigeria. rotimidamilare1@gmail.com.

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|July 5, 2022
PubMed
Summary

The nuclear factor erythroid-derived 2 (Nrf2) pathway influences testicular function and dysfunction. Activating Nrf2 shows therapeutic potential for infertility, while inhibitors may worsen testicular issues.

Keywords:
Cellular stressesNrf2Oxidative stressSpermTesticular dysfunction

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Area of Science:

  • Reproductive Biology
  • Molecular Toxicology
  • Cellular Stress Response

Background:

  • Testicular dysfunction is a key cause of infertility.
  • Oxidative stress and reactive oxygen species (ROS) are linked to abnormal sperm function.
  • The nuclear factor erythroid-derived 2 (Nrf2) pathway regulates cellular responses to stress.

Purpose of the Study:

  • To review the therapeutic role of Nrf2 in testicular function and dysfunction.
  • To explore Nrf2's influence on spermatogenesis, oxidative stress, and inflammation in the testis.
  • To identify potential Nrf2 activators and inhibitors for treating testicular disorders.

Main Methods:

  • Comprehensive literature search across major scientific databases (Elsevier, Wiley, Web of Science, Springer, PubMed, Taylor and Francis, Google Scholar).
  • Keywords used included "Nrf2," "testis," "sperm," "testicular function," and "testosterone."
  • Review and synthesis of existing scientific data on Nrf2's role in testicular physiology and pathology.

Main Results:

  • Nrf2 plays a significant role in testicular physiology and pathology, particularly in spermatogenesis.
  • Nrf2 regulates cellular resistance to oxidative stress, inflammation, and toxicants within the testis.
  • Nrf2 activators demonstrate potential therapeutic benefits for testicular dysfunction, while inhibitors may induce it.

Conclusions:

  • Nrf2 activation is a promising therapeutic target for addressing testicular dysfunction and infertility.
  • Understanding Nrf2 activators and inhibitors is crucial for developing treatments for male reproductive health issues.
  • Nrf2's regulation of antioxidant genes and cellular stress pathways highlights its importance in maintaining testicular health.