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Problems with generic theophylline and indiscriminate brand switching
Annals of Allergy
|May 1, 1987
Summary
Theophylline is effective for bronchospastic disorders but has a narrow therapeutic range. Understanding its pharmacokinetics is crucial to avoid toxicity when changing formulations or due to various influencing factors.
Area of Science:
- Pharmacology
- Clinical Pharmacy
- Respiratory Medicine
Background:
- Theophylline is a key medication for managing bronchospastic disorders.
- It possesses a narrow therapeutic range (10-20 µg/mL), necessitating careful management.
- Numerous factors, including infections, fever, diet, and drug interactions, can alter theophylline pharmacokinetics.
Purpose of the Study:
- To highlight the critical importance of understanding theophylline pharmacokinetics.
- To guide physicians in selecting appropriate theophylline preparations and timing of serum level monitoring.
- To inform about potential toxic effects from indiscriminate substitution of theophylline formulations.
Main Methods:
- Review of pharmacokinetic principles related to theophylline.
- Analysis of factors influencing theophylline metabolism and elimination.
- Discussion of clinical implications for patient management and safety.
Main Results:
- Serum theophylline levels are influenced by dosage, formulation, and timing of blood draw.
- Variability in pharmacokinetics requires individualized patient monitoring.
- Inappropriate formulation changes can lead to theophylline toxicity.
Conclusions:
- Accurate pharmacokinetic data is essential for safe and effective theophylline therapy.
- Physicians must consider individual patient factors and drug formulation when prescribing theophylline.
- Awareness of potential toxicities is vital to prevent adverse events in patients with bronchospastic disorders.