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Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
Published on: January 28, 2021
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Triglyceride Metabolism Modifies Lipoprotein(a) Plasma Concentration
Maria Ramos-Cáceres1, Itziar Lamiquiz-Moneo1,2, Ana Cenarro1,3
1Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón (IIS Aragón), CIBERCV, Zaragoza 50009, Spain.
The Journal of Clinical Endocrinology and Metabolism
|July 5, 2022
Summary
Higher triglycerides correlate with lower Lipoprotein(a) (Lp(a)) levels. Larger, apoE-rich VLDL particles are associated with reduced Lp(a), suggesting a role in cardiovascular risk management.
Area of Science:
- Cardiovascular Science
- Lipid Metabolism
- Genetics
Background:
- Lipoprotein(a) (Lp(a)) is a key independent risk factor for cardiovascular disease.
- Understanding Lp(a) regulation is crucial for developing targeted therapies.
- Triglycerides (TGs) and very-low-density lipoproteins (VLDL) are implicated in cardiovascular health.
Purpose of the Study:
- To investigate the relationship between triglycerides (TGs) and Lipoprotein(a) (Lp(a)) concentrations.
- To explore the influence of TG-rich lipoprotein characteristics and APOE genotype on Lp(a) levels.
- To analyze these associations cross-sectionally and longitudinally.
Main Methods:
- Utilized data from three large cohorts: Aragon Workers Health Study (AWHS), National Health and Nutrition Examination Survey III (NHANES III), and Hospital Universitario Miguel Servet (HUMS).
- Employed regression models adjusted for age and sex to assess associations.
- Quantified TG-rich lipoproteins, apolipoproteins (apo)B and apoE, and performed APOE genotyping.
Main Results:
- An inverse relationship was observed between TG and Lp(a) levels across all studies.
- Increased VLDL particle number, size, and TG content were associated with significantly lower Lp(a).
- Lower Lp(a) levels were linked to higher apoE concentration within VLDL and the presence of the apoE2/E2 genotype.
Conclusions:
- Findings confirm an inverse association between Lp(a) and TG concentrations.
- Larger VLDL particle size and VLDL enrichment with apoE are associated with reduced Lp(a) levels.
- The apoE genotype, particularly apoE2/E2, influences Lp(a) concentrations, suggesting potential therapeutic targets.
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