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Recurrent vincristine-associated fever in a child with Wilms tumor

Eman T Al-Antary1,2, Sarah Ramiz1,2

  • 1Division of Pediatric Hematology-Oncology, Department of Pediatrics, Children's Hospital of Michigan, Detroit, Michigan, USA.

Cancer Reports (Hoboken, N.J.)
|July 5, 2022
PubMed

Insights

Fever during chemotherapy is common in pediatric cancer patients. This case highlights rare vincristine-induced fever managed with prophylactic dexamethasone and acetaminophen.

Area of Science:

  • Pediatric Oncology
  • Clinical Pharmacology

Background:

  • Fever is a frequent complication in pediatric cancer patients undergoing chemotherapy, particularly during neutropenia.
  • While chemotherapy-induced fever is documented for various agents, fever linked to vincristine (VCR) is infrequently reported.

Observation:

  • A 5-year-old female with stage III Wilms tumor experienced recurrent fevers during VCR treatment.
  • These fevers were effectively managed using a prophylactic regimen of dexamethasone and acetaminophen.

Findings:

  • Recurrent VCR-associated fever can occur in pediatric cancer patients.
  • Prophylactic dexamethasone and acetaminophen demonstrated efficacy in controlling VCR-induced fever in this case.

Implications:

  • Consider febrile allergic reactions and prophylactic treatment for recurrent VCR-associated fever after excluding other causes.
  • This case suggests a potential management strategy for a rare but significant chemotherapy side effect.
Abstract

Keywords:
acetaminophendexamethasonefeverpediatricvincristine

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