Application of DSM-BIA in dry weight assessment in continuous ambulatory peritoneal dialysis

Dry weight assessment (DWA) is an important part of dialysis and fluid management in patients receiving renal replacement therapy. With the development of bioimpedance analysis (BIA), the development of the direct segmental multi-frequency BIA (DSM-BIA) has provided a more convenient measure for DWA of dialysis patients, but its accuracy remains unclear. This study was designed to evaluate the application of DSM-BIA in DWA of continuous ambulatory peritoneal dialysis (CAPD) patients.

This is a cross-sectional study. Using the conventional BIA as a reference, we examined the accuracy of the DSM-BIA technique for assessing dry weight in CAPD patients and analyzed the potential factors influencing their fluid volume status.

A total of 31 patients with end-stage renal disease receiving CAPD and 310 healthy volunteers were recruited for this study.

The intraclass correlation coefficients (ICC) and Bland-Altman plots were used to assess the consistency between DSM-BIA and the conventional BIA for DWA. Univariate and multivariate linear regression analyses were used to explore the influencing factors associated with the edema index.

DSM-BIA and the conventional BIA technology were consistent in DWA in CAPD patients (ICC female 0.972, ICC male 0.882, ICC total 0.960). Similarly, Bland-Altman plots showed good agreements between the two methods in DWA for both genders. Univariate and multivariate linear regression analysis showed both eGFR level (P = 0.04) and serum NT-pro BNP concentration (P = 0.007) were positively correlated with the ratio of extracellular water to total body water (ECW/TCW).

DSM-BIA in DWA has good accuracy in clinical applications and has potential application value for fluid volume management in CAPD patients.