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Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

786
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
786
Pain01:20

Pain

620
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
620
Nociception01:44

Nociception

29.4K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
29.4K

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Related Experiment Video

Updated: Sep 5, 2025

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
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Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

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Acute pain pathways: protocol for a prospective cohort study.

Molly Moore Jeffery1, Mitra Ahadpour2, Summer Allen3

  • 1Emergency Medicine and Health Care Delivery Research, Mayo Clinic, Rochester, Minnesota, USA jeffery.molly@mayo.edu.

BMJ Open
|July 5, 2022
PubMed
Summary
This summary is machine-generated.

This study examines acute pain management in 1550 opioid-naïve patients, tracking opioid analgesic use and patient outcomes over six months. Findings will inform evidence-based guidelines for acute pain control.

Keywords:
accident & emergency medicineoral & maxillofacial surgerypain managementprimary care

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Area of Science:

  • Pain Management
  • Clinical Research
  • Observational Studies

Background:

  • Limited high-quality evidence exists for prescribing opioid analgesics for moderate-to-severe acute non-cancer pain.
  • Understanding pain management and control in acute pain is crucial for developing evidence-based guidelines.

Purpose of the Study:

  • To assess patterns of pain and opioid analgesic use in opioid-naïve patients with acute pain.
  • To investigate associations between patient/condition characteristics and patient-centered outcomes.
  • To analyze the management of leftover opioids.

Main Methods:

  • Multicentre prospective observational study of 1550 opioid-naïve participants.
  • Six-month follow-up using a patient-centered health data aggregating platform.
  • Inclusion of diverse races, ethnicities, pain conditions, and geographical locations.

Main Results:

  • Data analysis will focus on pain and opioid use patterns.
  • Examining associations between patient/condition factors and outcomes like pain resolution and satisfaction.
  • Descriptive analysis of leftover opioid management.

Conclusions:

  • The study aims to provide crucial data for evidence-based guidelines in acute pain management.
  • Findings will enhance understanding of patient experiences and outcomes with opioid analgesics.
  • Results will contribute to improved clinical prescribing practices for acute pain.